Evaluation of cofactor effect of feline syncytium-forming virus on feline immunodeficiency virus infection.
Evaluation of cofactor effect of feline syncytium-forming virus on feline immunodeficiency virus infection.
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猫合胞体形成病毒对猫免疫缺陷病毒感染的辅助因子作用评价。
DOI：
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发表时间：
1993
影响因子：
1
通讯作者：
E. Collisson
中科院分区：
文献类型：
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作者：
Elisabeth Zenger;W. Brown;Wenru Song;Alice M. Wolf;Niels C Pedersen;M. Longnecker;Junzhou Li;E. Collisson
虽然猫免疫缺陷病毒（FIV）和不相关的逆转录病毒猫白血病病毒（FeLV）与猫的获得性免疫缺陷相关，但实验和现场证据表明，两种病毒的合并感染可能导致更严重的疾病综合征。第三种猫逆转录病毒，即猫合胞体形成病毒（FeSFV），其流行率远高于FIV或FeLV，被认为在本质上是非致病性的，一直从患病的FIV感染猫中共分离出。为了确定FeSFV在增强FIV介导的疾病中的潜在作用，在24只9月龄猫中的14只中建立了持续性FeSFV感染。四个月后，一半的FeSFV感染的猫和一半的未感染的猫接种血液获得的猫持续感染的Petaluma株的FIV。在接种后第17周，1只仅感染FIV的公猫死于细菌性支气管肺炎，这可能归因于FIV诱导的获得性免疫缺陷样综合征。然而，其余猫均未出现临床疾病，无论是单独感染病毒还是合并感染两种病毒。早在接种后第6周，就观察到接种FIV的两组猫的CD 4 +/CD 8 + T淋巴细胞比率降低。FeSFV感染对CD 4+与CD 8 + T细胞比率没有影响。有丝分裂原刺激试验和总WBC计数不受FeSFV感染的影响，尽管FeSFV感染猫的中性粒细胞数量增加是一致的，特别是与FIV感染后观察到的减少相比。（250字处删节）
Although feline immunodeficiency virus (FIV) and the unrelated retrovirus feline leukemia virus (FeLV) are associated with acquired immune deficiency in cats, experimental and field evidence indicates that coinfection with both viruses may lead to more serious disease syndrome. A third feline retrovirus, feline syncytium-forming virus (FeSFV), which is far more prevalent than either FIV or FeLV and is considered nonpathogenic in nature, is consistently coisolated from sick, FIV-infected cats. To determine the potential role of FeSFV in enhancement of FIV-mediated disease, persistent FeSFV infection was established in 14 of 24 nine-month-old cats. Four months later, half the FeSFV-infected and half the noninfected cats were inoculated with blood obtained from a cat persistently infected with the Petaluma strain of FIV. At postinoculation week 17, 1 male cat infected with only FIV died of bacterial bronchopneumonia that could have been attributed to FIV-induced acquired immune deficiency-like syndrome. However, none of the remaining cats had clinical illness, whether infected with either virus alone or coinfected with both viruses. As early as postinoculation week 6, decreases were observed in the CD4+ to CD8+ T-lymphocyte ratio of both groups of cats inoculated with FIV. Infection with FeSFV had no effect on the CD4+ to CD8+ T-cell ratio. Mitogen stimulation assays and total WBC count were unaffected by FeSFV infection, although an increase in numbers of neutrophils from FeSFV-infected cats was consistent, especially when compared with the decrease observed after FIV infection.(ABSTRACT TRUNCATED AT 250 WORDS)