Tumor suppression with a combination of alpha-difluoromethyl ornithine and interferon.
Tumor suppression with a combination of alpha-difluoromethyl ornithine and interferon.
复制标题
α-二氟甲基鸟氨酸和干扰素的组合可抑制肿瘤。
作者：
P. Sunkara;N. J. Prakash;G. D. Mayer;A. Sjoerdsma
当同时给予α-二氟甲基鸟氨酸和小鼠1型干扰素时，对培养的B16黑素瘤细胞具有高毒性。口服α-二氟甲基鸟氨酸抑制小鼠B16黑色素瘤的发展85%，而皮下注射干扰素仅抑制肿瘤生长24%。在接受两种治疗的小鼠中观察到肿瘤生长的完全或接近完全抑制。
alpha-Difluoromethyl ornithine and mouse type 1 interferon, when administered simultaneously, were highly toxic to B16 melanoma cells in culture. Oral administration of alpha-difluoromethyl ornithine suppressed B16 melanoma development in mice 85 percent whereas interferon given subcutaneously inhibited tumor growth only 24 percent. Total or near total suppression of tumor growth was observed in mice receiving both treatments.