Human relaxins: chemistry and biology.
Human relaxins: chemistry and biology.
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DOI：
10.1210/edrv-15-1-5
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发表时间：
1994-02
影响因子：
20.3
通讯作者：
G. Bryant-Greenwood;C. Schwabe
中科院分区：
文献类型：
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作者：
G. Bryant-Greenwood;C. Schwabe
从杂志上第一次对松弛素的评论到现在已经有十多年了。我们和其他人回顾了这一时期的许多重大进展（2-4）。在过去的几年里，人类松弛素基因HI和H2的测序，以及这些肽和抗体的可用性，使得知识的进步相对较快。有足够的累积数据来保证在该领域的专业化，并允许我们将这篇综述集中在人类松弛素上。在人类松弛素对人体系统的影响的知识方面存在空白的地方，它们已经被来自非人类动物实验的数据所填补，以提供该领域状况的更完整的图景。表1概述了1983-1992年期间的主要预付款。在此期间，研究人员描述了两种人类松弛素基因的序列及其组织表达，以及它们的化学合成和重组合成。
IT IS more than a decade since the previous and first review in this journal on relaxin (1). There have been many significant advances over this period which have been reviewed by us and others (2–4). The sequencing of the two human relaxin genes termed HI and H2 relaxins, and the availability of these peptides and antibodies have allowed relatively rapid progress in knowledge over the last few years. There is enough accumulated data to warrant specialization within the field and to allow us to focus this review on the human relaxins. Where there are gaps in the knowledge of effects of human relaxin in human systems, they have been filled with data from nonhuman animal experimentation to provide a more complete picture of the status of the field. A summary of the principal advances over the period 1983–1992 is presented in Table 1. Over this period the sequences of the two human relaxin genes as well as their tissue expression were described together with the chemical and recombinant syntheses of their pe...