Hepatocellular carcinoma and non-Hodgkin's lymphoma: The roles of HIV, hepatitis C infection, and alcohol abuse
Hepatocellular carcinoma and non-Hodgkin's lymphoma: The roles of HIV, hepatitis C infection, and alcohol abuse
复制标题
DOI：
10.1200/jco.2006.05.7984
复制
发表时间：
2006-11-01
影响因子：
45.3
通讯作者：
Justice, Amy C.
中科院分区：
文献类型：
--
作者：
McGinnis, Kathleen A.;Fultz, Shawn L.;Justice, Amy C.
PurposeTo explore the relationship of HIV, hepatitis C (HCV), and alcohol abuse/dependence to risk for hepatocellular carcinoma and non-Hodgkin's lymphoma (NHL).Patients and MethodsMale veterans ( n = 14,018) with a first HIV diagnosis in the Veterans Affairs Healthcare System from October 1997 to September 2004; and 28,036 age-, race-, sex-, and location-matched HIV-negative veterans were identified. We examined the incidence of hepatocellular carcinoma and NHL and presence of HCV and alcohol abuse/dependence using International Classification of Diseases, ninth revision (ICD-9-CM) codes. HIV-positive to HIV-negative incident rate ratios (IRRs) and 95% CIs for the occurrence of hepatocellular carcinoma and NHL were calculated using Poisson regression models.ResultsHIV-positive veterans were at greater risk for hepatocellular carcinoma than HIV-negative veterans (IRR = 1.68; 95% CI, 1.02 to 2.77). After adjusting for HCV infection and alcohol abuse/ dependence, HIV status was not independently associated with hepatocellular cancer ( IRR = 0.96; 95% CI, 0.56 to 1.63). HIV-positive veterans had 9.71 times ( 95% CI, 6.99 to 13.49) greater risk of NHL than HIV-negative veterans. After adjusting for HCV and alcohol abuse/ dependence, the IRR for NHL comparing HIV-positive with HIV-negative veterans is similar ( IRR = 10.03, 95% CI, 7.19 to 13.97).ConclusionHIV-positive veterans have a higher relative incidence of hepatocellular carcinoma and NHL than HIV-negative veterans. For hepatocellular carcinoma, this association appears to be largely explained by the higher prevalence of HCV and alcohol abuse/ dependence. Efforts to decrease hepatocellular carcinoma among persons with HIV should focus primarily on detecting and treating HCV and reducing heavy alcohol use.
