Parental separation in childhood and adult inflammation: The importance of material and psychosocial pathways
Parental separation in childhood and adult inflammation: The importance of material and psychosocial pathways
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DOI：
10.1016/j.psyneuen.2013.05.007
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发表时间：
2013-11-01
影响因子：
3.7
通讯作者：
McMunn, Anne
中科院分区：
文献类型：
--
作者：
Lacey, Rebecca E.;Kumari, Meena;McMunn, Anne
背景：众所周知，童年逆境与健康状况较差有关。一个潜在的机制可能是通过炎症过程的变化。一个这样的童年逆境是父母分离，但相对而言，父母分离和成年炎症之间的关联知之甚少。本研究的目的是（1）调查父母分离是否与中年炎症有关，（2）关注可能参与将童年逆境（如父母分离）转化为成年后更差健康结果的机制。方法：我们研究了童年时期父母分居的关系，定义为父母伙伴关系的破裂，和中年时C反应蛋白（CRP）水平。材料所起的作用（由于物质上的不利条件和教育程度）、心理社会（通过亲子关系质量和心理困扰）和肥胖症在英国出生队列的多重插补数据集中使用路径分析研究了（通过BMI）机制，并在整个生命过程中进行了同步测量结果：父母分居的参与者在44岁时的CRP水平高于与父母一起长大的参与者（β = 0.16，95%CI：0.06，0.27）。这种关联在很大程度上是由BMI、物质和心理社会因素解释的。分离后的物质劣势和教育程度似乎是特别重要的，在此association.Conclusions：父母分离增加CRP在成年后通过链的不利在整个生命历程。这项研究指出了潜在的干预点，并强调需要支持分离的家庭，以尽量减少对成人健康的长期影响。(C)2013作者由爱思唯尔有限公司出版。保留所有权利。
Background: Childhood adversities are known to be associated with poorer health outcomes. A potential mechanism may be through changes in inflammatory processes. One such childhood adversity is separation of parents, however relatively little is known about the association between parental separation and inflammation in adulthood. The aims of this study were to (1) investigate whether parental separation is associated with inflammation in mid-life, (2) focus upon the mechanisms that may be involved in translating childhood adversities, such as parental separation, into poorer health outcomes in adulthood.Methods: We examine the association of parental separation in childhood, defined as the breakdown of the parent's partnership, and levels of C-reactive protein (CRP) in middle age. The role played by material (through material disadvantage and educational attainment), psychosocial (through parent child relationship quality and psychological distress) and adiposity (through BMI) mechanisms is investigated using path analysis in a multiply-imputed dataset from a British birth cohort with concurrent measurements made throughout the life course (n = 7462).Results: Participants that report parental separation have higher CRP levels at age 44 than those who grew up with both parents (beta = 0.16, 95% CI: 0.06, 0.27). This association is largely explained by BMI, material and psychosocial factors. Material disadvantage after separation and educational attainment seem to be particularly important in this association.Conclusions: Parental separation increases CRP in adulthood via chains of disadvantage across the life course. This study points towards potential points for intervention and highlights a need to support separating families in order to minimise the long-term impact on adult health. (C) 2013 The Authors. Published by Elsevier Ltd. All rights reserved.