Biocompatible polysaccharide-based cryogels.
Biocompatible polysaccharide-based cryogels.
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DOI：
10.1016/j.msec.2013.10.034
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发表时间：
2014-02
期刊：
影响因子：
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通讯作者：
S. Reichelt;J. Becher;J. Weisser;A. Prager;U. Decker;S. Möller;A. Berg;M. Schnabelrauch
中科院分区：
文献类型：
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作者：
S. Reichelt;J. Becher;J. Weisser;A. Prager;U. Decker;S. Möller;A. Berg;M. Schnabelrauch
本研究以可聚合右旋糖酐和透明质酸衍生物为原料，通过电子束辅助自由基交联反应，制备了具有生物相容性的大孔冻凝胶。作为主要优点，这种直接的方法提供了高孔隙率的高纯材料，而不使用额外的交联剂或引发剂。的冷冻凝胶，其特征在于关于它们的形态和它们的基本性能，包括热和机械特性，和溶胀性。结果发现，所施加的辐射剂量和化学组成强烈影响所得到的冷冻凝胶的材料性质。初步的细胞毒性测试说明了所制造的冷冻凝胶的优异的体外细胞相容性，使得它们作为组织再生程序中的基质特别有吸引力。
This study focuses on the development of novel biocompatible macroporous cryogels by electron-beam assisted free-radical crosslinking reaction of polymerizable dextran and hyaluronan derivatives. As a main advantage this straightforward approach provides highly pure materials of high porosity without using additional crosslinkers or initiators. The cryogels were characterized with regard to their morphology and their basic properties including thermal and mechanical characteristics, and swellability. It was found that the applied irradiation dose and the chemical composition strongly influence the material properties of the resulting cryogels. Preliminary cytotoxicity tests illustrate the excellent in vitro-cytocompatibility of the fabricated cryogels making them especially attractive as matrices in tissue regeneration procedures.