Differences in ornithine decarboxylase and androgen receptor allele frequencies among ethnic groups.
Differences in ornithine decarboxylase and androgen receptor allele frequencies among ethnic groups.
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不同种族之间鸟氨酸脱羧酶和雄激素受体等位基因频率的差异。
DOI：
10.1002/mc.20047
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Watkins-Bruner,D
中科院分区：
文献类型：
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作者：
O'Brien,ThomasG;Guo,Y;Visvanathan,K;Sciulli,J;McLaine,M;Helzlsouer,KJ;Watkins-Bruner,D
最近的证据表明，鸟氨酸脱羧酶 (ODC) 基因的 A 等位基因是前列腺癌的遗传风险因素。ODC 是高度多态性雄激素受体 (AR) 基因的靶基因，一些研究表明该基因的短等位基因与前列腺癌风险增加有关。我们确定了美洲白种人、非裔美国人、西班牙裔、欧洲人和非洲人中 OD 等位基因的频率和 AR 等位基因的分布。 theODCA 等位基因的频率从 0.183（西班牙裔、欧洲人）到 0.415（非洲人）不等，美国白种人和非裔美国人的频率处于中间值。 AR 基因中 CAG 重复的平均数量从 19.8（非洲裔美国人）到 25.1（西班牙裔）不等。 ODC 和 AR 风险等位基因的种族差异可能是前列腺癌风险的一些种族差异的原因。 © 2004 Wiley-Liss, Inc.
Recent evidence suggests that the A allele of the ornithine decarboxylase (ODC) gene is a genetic risk factor for prostate cancer.ODCis a target gene of the highly polymorphic androgen receptor (AR) gene, short alleles of which have been associated in some studies with increased prostate cancer risk. We determinedODCallele frequencies and distribution ofARalleles in American Caucasians, African‐Americans, Hispanics, Europeans, and Africans. The frequency of theODCA allele varied from 0.183 (Hispanics, Europeans) to 0.415 (Africans) with American Caucasian and African‐Americans having intermediate values. The mean number of CAG repeats in theARgene varied from 19.8 (African‐Americans) to 25.1 (Hispanics). It is possible that ethnic differences in risk alleles forODCandARmay account for some of the ethnic variation in prostate cancer risk. © 2004 Wiley‐Liss, Inc.