Prevalence of lipodystrophy in HIV-infected children: a cross-sectional study
Prevalence of lipodystrophy in HIV-infected children: a cross-sectional study
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DOI：
10.1007/s00431-006-0193-1
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发表时间：
2007-01-01
影响因子：
3.6
通讯作者：
Levy, Jack
中科院分区：
文献类型：
--
作者：
Ene, Luminita;Goetghebuer, Tessa;Levy, Jack
目的本研究的目的是评估在一个单一的中心谁曾接触过，或没有，以抗逆转录病毒疗法（ART）.Materials and Methods患者年龄在3至19岁之间进行了评价，在2002年10月至12月之间进行的横断面研究中的HIV感染的儿童和青少年的体脂分布和血脂异常的变化。由医生和患者独立评价脂肪再分布。检测空腹血脂、血糖、胰岛素、C肽。结果20例患儿存在脂肪再分布，22例患儿存在单纯代谢改变，46例患儿无体格或代谢异常。发现脂肪再分布的患者接受抗逆转录病毒治疗的时间明显更长，42%的脂肪再分布儿童接受抗逆转录病毒药物治疗超过5年。这些儿童还接触了更多的抗逆转录病毒药物。相反，在没有脂肪再分布的情况下，代谢改变与ART的持续时间和接受的药物数量无关。与司他夫定或蛋白酶抑制剂的治疗显着相关的存在物理changes.Conclusion脂肪再分布和代谢标志物的定期评估应进行抗逆转录病毒药物治疗的儿童，并考虑到适应治疗时，在长期随访这些儿童。
Objective The aim of this study was to assess the changes in body fat distribution and lipid abnormalities in a population of HIV-infected children and adolescents followed in one single centre who had been exposed, or not, to antiretroviral therapy (ART).Materials and methods Patients aged between 3 and 19 years were evaluated in a cross-sectional study carried out between October and December 2002. Fat redistribution was evaluated independently by the physician and the patient. Fasting blood lipid profile, glucose, insulin and C peptide were measured. Among the 88 patients evaluated, 74 were taking ART.Results Fat redistribution was present in 20 patients, metabolic alterations alone were found in 22 children and 46 children had neither physical nor metabolic abnormalities. Patients with fat redistribution were found to have been on ART for a significantly longer period of time, with 42% of the children showing fat redistribution having been treated with anitretroviral agents for more than 5 years. These children had also been exposed to a higher number of antiretroviral agents. In contrast, metabolic alterations in the absence of fat redistribution were not related to the duration of ART nor to the number of drugs received. Treatment with stavudine or protease inhibitors was significantly associated with the presence of physical changes.Conclusion Regular assessment of fat redistribution and metabolic markers should be carried out in children treated with antiretroviral agents and taken into account when adapting therapy during the long-term follow up of these children.