Ionic channels in smooth muscle studied with patch-clamp methods.
Ionic channels in smooth muscle studied with patch-clamp methods.
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用膜片钳方法研究平滑肌中的离子通道。
DOI：
10.2170/jjphysiol.38.1
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
T. Tomita
中科院分区：
文献类型：
--
作者：
T. Tomita
膜片钳技术在平滑肌上的应用仅在几年前才开始，但已经出现了许多出版物。到目前为止，在平滑肌中发现的Ca和K通道似乎与其他组织中的Ca和K通道基本相似。然而，与心肌相反，平滑肌中的Ca通道可能不受环AMP控制。钙通道至少有两种不同的类型（“快”和“慢”），但它们在不同平滑肌中的相对分布及其生理意义尚未完全分析。此外，受体操纵的Ca通道的分析仍然是非常有限的，虽然这些通道是非常重要的平滑肌功能。需要进一步仔细的研究来检查不同类型的Ca通道中涉及的调节机制，并阐明受体操纵的通道。也有不同的（电压和钙激活）类型的K通道。钙激活的钾通道似乎在许多平滑肌中占主导地位，并调节其兴奋性。然而，K通道负责静息电位或自发活动应被定义，也贡献的K（和其他离子）通道受体介导的反应仍有待研究。
Application of the patch-clamp technique on smooth muscle has started only a few years ago, but many publications are already emerging. The Ca and K channels so far found in smooth muscles seem to be fundamentally similar to those in other tissues. However, it is likely that Ca channel in smooth muscle is not controlled by cyclic AMP, in contrast to the cardiac muscle. There are at least two different ("fast" and "slow") types of Ca channel, but their relative distribution in different smooth muscles and their physiological significance are not yet fully analyzed. Furthermore, analysis of the receptor-operated Ca channels is still very limited, although these channels are very important for the smooth muscle function. Further careful studies are necessary to examine regulatory mechanisms involved in different types of Ca channel and to clarify the receptor-operated channel. There are also different (voltage- and Ca-activated) types of K channel. The Ca-activated K channel seems predominant in many smooth muscles ad regulating their excitability. However, K channels responsible for the resting potential or for spontaneous activity should be defined and also contribution of K (and other ionic) channels to receptor-mediated responses remains to be investigated.
DOI：
10.1126/science.2425434
发表时间：
1986
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Sturek,M;Hermsmeyer,K
通讯作者：
Hermsmeyer,K
来自隐静脉的分离平滑肌细胞的全细胞和单通道钙电流。
影响因子：
20.1
作者：
Yatani,A;Seidel,CL;Allen,J;Brown,AM
通讯作者：
Brown,AM
乙酰胆碱可增加新分离的平滑肌细胞中电压激活的 Ca2 电流。
DOI：
10.1073/pnas.84.7.2092
发表时间：
1987
影响因子：
11.1
作者：
Clapp,LH;Vivaudou,MB;WalshJr,JV;Singer,JJ
通讯作者：
Singer,JJ