COMPARATIVE PHARMACOKINETICS OF SILIPIDE AND SILYMARIN IN RATS
COMPARATIVE PHARMACOKINETICS OF SILIPIDE AND SILYMARIN IN RATS
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DOI：
10.1007/bf03188811
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发表时间：
1993-07-01
影响因子：
1.9
通讯作者：
PIFFERI, G
中科院分区：
文献类型：
--
作者：
MORAZZONI, P;MONTALBETTI, A;PIFFERI, G
在大鼠单次等摩尔口服剂量（200 mg/kg，表示为水飞蓟宾当量）水飞蓟宾-磷脂酰胆碱复合物硅脂（实验室代码 IdB 1016）和水飞蓟素后，对水飞蓟宾（水飞蓟素的主要黄烷木脂素成分）的血浆水平和胆汁排泄进行了评估。使用特定的 HPLC 方法对水飞蓟宾进行测定，该方法还可以测定施用水飞蓟素后生物体液中存在的其他黄烷木脂素（即水飞蓟宁、水飞蓟丁和异水飞蓟宾）。
The plasma level profile and the biliary excretion of silybin, the main flavanolignan component of silymarin, were evaluated in rats after single equimolar oral doses (200 mg/kg, expressed as silybin equivalents) of the silybin-phosphatidylcholine complex silipide (laboratory code IdB 1016) and of silymarin. Silybin was assayed by using a specific HPLC method which allowed also the determination of other flavanolignans present in the biological fluids after administration of silymarin (i.e. silydianin, silycristin and isosilybin).