The journey to autism: Insights from neuroimaging studies of infants and toddlers.
The journey to autism: Insights from neuroimaging studies of infants and toddlers.
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DOI：
10.1017/s0954579417000980
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发表时间：
2018-05
影响因子：
3.3
通讯作者：
Elison JT
中科院分区：
文献类型：
--
作者：
Wolff JJ;Jacob S;Elison JT
根据定义，自闭症谱系障碍（ASD）是一种在儿童早期出现的神经发育障碍。在此期间，婴儿和幼儿从多个领域的典型表现过渡到表现出ASD的行为表型。神经影像学研究集中在这一时期的发展提供了有关这一进程的重要知识，包括潜在的发病机制的障碍，并提供前驱或症状前的风险预测的可能性。在本文中，我们回顾了ASD的结构和功能脑成像研究的结果，重点是生命的第一年，并讨论了下一步的研究和临床应用的影响。
By definition, autism spectrum disorder (ASD) is a neurodevelopmental disorder that emerges during early childhood. It is during this time that infants and toddlers transition from appearing typical across multiple domains to exhibiting the behavioral phenotype of ASD. Neuroimaging studies focused on this period of development have provided crucial knowledge pertaining to this process, including possible mechanisms underlying pathogenesis of the disorder and offering the possibility of prodromal or presymptomatic prediction of risk. In this paper, we review findings from structural and functional brain imaging studies of ASD focused on the first years of life and discuss implications for next steps in research and clinical applications.