Treatment outcomes of macrolide-susceptible Mycobacterium abscessus lung disease
Treatment outcomes of macrolide-susceptible Mycobacterium abscessus lung disease
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DOI：
10.1016/j.diagmicrobio.2017.12.008
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发表时间：
2018-04-01
影响因子：
2.9
通讯作者：
Koh, Won-Jung
中科院分区：
文献类型：
--
作者：
Choi, Hayoung;Jhun, Byung Woo;Koh, Won-Jung
由于对大环内酯类药物具有诱导耐药性，脓肿分枝杆菌肺部疾病难以治疗。然而，15%-20%的分离株对大环内酯类敏感。 14例大环内酯类敏感脓肿分枝杆菌肺部疾病患者中，所有分离株均具有非功能性erm(41)基因，抗生素治疗后痰培养转化率达到93%（13/14）。 (C) 2017 Elsevier Inc. 保留所有权利。
Mycobacterium abscessus lung disease is difficult to treat due to inducible resistance to macrolides. However, 15%-20% of isolates are macrolide susceptible. In 14 patients with macrolide-susceptible M. abscessus lung disease, all isolates had nonfunctional erm(41) gene, and sputum culture conversion rate was achieved in 93% (13/14) following antibiotic therapy. (C) 2017 Elsevier Inc. All rights reserved.