Toll-Like Receptor 2/6 Agonist Macrophage-Activating Lipopeptide-2 Promotes Reendothelialization and Inhibits Neointima Formation After Vascular Injury
Toll-Like Receptor 2/6 Agonist Macrophage-Activating Lipopeptide-2 Promotes Reendothelialization and Inhibits Neointima Formation After Vascular Injury
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DOI：
10.1161/atvbaha.113.301799
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发表时间：
2013-09-01
影响因子：
8.7
通讯作者：
Schieffer, Bernhard
中科院分区：
文献类型：
--
作者：
Grote, Karsten;Sonnenschein, Kristina;Schieffer, Bernhard
目的：血管损伤后再内皮化（即球囊血管成形术或支架植入术）对促进血管愈合具有重要的临床意义。我们在这里研究了toll样受体2/6激动剂巨噬细胞激活脂肽(MALP)-2对血管损伤小鼠模型的再内皮化和新内膜形成的治疗潜力。方法与结果电损伤左颈总动脉，3天后Evans蓝染色定量观察再内皮化情况。血管损伤后单次注射MALP-2（1或10 μ g， IV）加速再内皮化(P
Objective-Reendothelialization after vascular injury (ie, balloon angioplasty or stent implantation) is clinically extremely relevant to promote vascular healing. We here investigated the therapeutic potential of the toll-like receptor 2/6 agonist macrophage-activating lipopeptide (MALP)-2 on reendothelialization and neointima formation in a murine model of vascular injury.Approach and Results-The left common carotid artery was electrically injured, and reendothelialization was quantified by Evans blue staining after 3 days. A single injection of MALP-2 (1 or 10 mu g, IV) after vascular injury accelerated reendothelialization (P