Thymic non-lymphoid cells.
Thymic non-lymphoid cells.
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胸腺非淋巴细胞。
DOI：
10.1007/bf02918808
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Sharp,JG
中科院分区：
文献类型：
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作者：
Crouse,DA;Turpen,JB;Sharp,JG
在对胸腺结构/功能关系的西蒙纯知识进行总结时，我们认为可能已经到了引入适当剂量的愤世嫉俗的时候了，以平衡过去有时无望的乐观情绪。胸腺的非淋巴细胞是胸腺功能所必需的吗？有可能，但没有达到包括我们自己在内的一些作者之前声称的程度或独特性； T 细胞可能可以在其他组织中分化，但可能会偏好胸腺中的 MHC II 类。Scollay 和 Shortman 最近用图解法总结了小鼠胸腺淋巴细胞的运输和表面表型[95]。简而言之，细胞在胸腺内孵化、匹配，然后分配。至少，非淋巴细胞要么充当沿途风景各异的障碍物，新生T细胞的托儿所，要么充当生命被剥夺权利、衰弱和自我攻击性胸腺细胞的墓碑。哈索尔小体是胸腺特有的形态结构，对于医学生识别这种组织最有用。它们的功能仍然是生命中最大的谜团之一。从形态学上讲，它们是最近描述的奇怪的淋巴细胞和上皮细胞多细胞复合体的合适伴侣，这些复合体可能具有重要的功能。人们经常对经过大量研究的近交系、环境溺爱的实验室小鼠的胸腺进行描述。这可能是人类和大多数哺乳动物的典型特征。然而，它可能不能代表受到压力和寄生的野生动物的胸腺。胸腺疾病通常可分为胸腺不足、胸腺肿瘤或胸腺不能正常工作。我们对胸腺非淋巴细胞的了解的底线是，如果你出生时没有它们，你就会生病和死亡；如果你出生时没有它们，你就会生病甚至死亡；当然，除非你是奥马哈的裸鼠，在这种情况下你就会被冻死。
In formulating this summary of our simon-pure knowledge of the structure/function relationships in the thymus, we decided that the time may have come to introduce a suitable dose of cynicism to balance the sometimes hopeless optimism of the past.Are the non-lymphoid cells of the thymus necessary for thymic function? Probably, but not to the extent or uniqueness that some authors including ourselves have previously claimed; T cells can probably differentiate in other tissues but may acquire their preference for MHC class II in the thymus.Mouse thymic lymphoid cell traffic and surface phenotype has recently been summarized pictorally byScollay and Shortman[95]. Briefly stated, within the thymus, cells are hatched, matched and then dispatched. Minimally, the non-lymphoid cells act either as scenically varied obstacles along the way, nurseries for newborn T cells, or as tombstones for life’s disenfranchized, effete and autoaggressive thymocytes. Hassall’s corpuscles are morphological structures unique to the thymus, which are most useful to medical students for identification of this tissue. Their function remains one of life’s great mysteries. Morphologically, they are suitable companions to the more recently described strange multicellular complexes of lymphocytes and epithelial cells which might be functionally important. The thymus of the much studied inbred, environmentally mollycoddled, laboratory mouse has been often and majestically described. It is probably typical for that of man and most mammals. It may, however, be unrepresentative of the thymus of stressed and parasitized wild animals. Diseases of the thymus generally can be categorized as not having enough thymus, having a neoplastic thymus or having a thymus which does not work properly. The bottom line in our knowledge of thymic non-lymphoid cells is that if you are born without them, you get sick and die; unless, of course, you are a nude mouse in Omaha, in which case you just freeze to death.