Decreased anogenital distance and increased incidence of undescended testes in fetuses of rats given monobenzyl phthalate, a major metabolite of butyl benzyl phthalate
Decreased anogenital distance and increased incidence of undescended testes in fetuses of rats given monobenzyl phthalate, a major metabolite of butyl benzyl phthalate
复制标题
DOI：
10.1016/s0890-6238(03)00037-6
复制
发表时间：
2003-07-01
影响因子：
3.3
通讯作者：
Kamata, E
中科院分区：
文献类型：
--
作者：
Ema, M;Miyawaki, E;Kamata, E
本研究的目的是确定邻苯二甲酸单苄酯 (MBeP)（邻苯二甲酸丁基苄酯 (BBP) 的主要代谢物）对生殖系统发育的不利影响，并评估 MBeP 在 BBP 的抗雄激素作用中的作用。怀孕大鼠在怀孕第 15-17 天按 167、250 或 375 mg/kg 灌胃给予 MBeP。怀孕第 21 天对胎儿进行检查。当剂量为 167 毫克/公斤或更高时，母亲的体重增加和食物消耗显着下降。胎儿体重在 375 mg/kg 时显着下降。在 250 mg/kg 及更高剂量下，发现男性胎儿睾丸未降的发生率显着增加，肛门生殖器距离 (AGD) 和 AGD 与体重立方根的比率降低。女性胎儿的AGD以及AGD与体重立方根的比值。 MBeP 治疗组的情况与对照组相当。目前的数据表明，MBeP 对男性后代生殖系统的发育产生不利影响，并表明 MBeP 可能是 BBP 的抗雄激素作用的原因。 (C) 2003 Elsevier Science Inc. 保留所有权利。
The objective of this study was to determine the adverse effects of monobenzyl phthalate (MBeP), a major metabolite of butyl benzyl phthalate (BBP), on the development of the reproductive system, and to assess the role of MBeP in the antiandrogenic effects of BBP. Pregnant rats were given MBeP by gavage at 167, 250, or 375 mg/kg on days 15-17 of pregnancy. Fetuses were examined on day 21 of pregnancy. Maternal body weight gain and food consumption were significantly decreased at 167 mg/kg and higher. Fetal weight was significantly decreased at 375 mg/kg. A significant increase in the incidence of undescended testes and decrease in the anogenital distance (AGD) and ratio of AGD to the cube root of body weight was found in male fetuses at 250 mg/kg and higher. The AGD and ratio of AGD to the cube root of body weight of female fetuses. in the MBeP-treated groups were comparable to those in the,control group. The present data indicate that MBeP produces adverse effects on the development of the reproductive system in male offspring and suggest that MBeP may be responsible for the antiandrogenic effects of BBP. (C) 2003 Elsevier Science Inc. All rights reserved.