EGL-10 regulates G protein signaling in the C-elegans nervous system and shares a conserved domain with many mammalian proteins
EGL-10 regulates G protein signaling in the C-elegans nervous system and shares a conserved domain with many mammalian proteins
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DOI：
10.1016/s0092-8674(00)80998-8
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发表时间：
1996-01-12
期刊：
影响因子：
64.5
通讯作者：
Horvitz, HR
中科院分区：
文献类型：
--
作者：
Koelle, MR;Horvitz, HR
线虫的某些周期性行为的频率。线虫以剂量依赖性方式受基因EGL-10活性的调节。这些行为被G蛋白α亚基基因果阿-1的活性相反地调节，表明egl-10可以以剂量依赖性方式调节G蛋白信号传导途径。egl-10编码类似于Sst 2 p的蛋白质，Sst 2 p是酵母中G蛋白信号传导的负调节因子。EGL-10蛋白定位于神经过程中，在那里它可能在神经递质信号传导中起作用。两个以前已知的和13个新发现的哺乳动物基因具有相似性egl-10和SST 2，我们建议，这个家庭的成员调节许多G蛋白信号通路。
The frequencies of certain periodic behaviors of the nematode C. elegans are regulated in a dose-dependent manner by the activity of the gene egl-10. These behaviors are modulated oppositely by the activity of the G protein alpha subunit gene goa-1, suggesting that egl-10 may regulate a G protein signaling pathway in a dose-dependent fashion. egl-10 encodes a protein similar to Sst2p, a negative regulator of G protein signaling in yeast. EGL-10 protein is localized in neural processes, where it may function in neurotransmitter signaling. Two previously known and 13 newly identified mammalian genes have similarity to egl-10 and SST2, and we propose that members of this family regulate many G protein signaling pathways.