Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer
Correlation of reversion-inducing cysteine-rich protein with kazal motifs (RECK) and extracellular matrix metalloproteinase inducer (EMMPRIN), with MMP-2, MMP-9, and survival in colorectal cancer
复制标题
DOI：
10.1016/j.canlet.2005.06.009
复制
发表时间：
2006-06-18
期刊：
影响因子：
9.7
通讯作者：
Span, Paul N.
中科院分区：
文献类型：
--
作者：
van der Jagt, Michel F. P.;Sweep, Fred C. G. J.;Span, Paul N.
63例结直肠癌患者的肿瘤组织中MMP-2和MMP-9的mRNA、潜伏和活性水平均高于正常组织，而RECK和EMMPRIN水平则较低。肿瘤组织中MMP-2的mRNA、潜伏性和活性MMP之间的相关性特别高（R-8 = 0.6-0.8）。P < 0.001）。线性回归分析证实，RECK与肿瘤组织中活性MMP-2呈显著负偏相关（R-p =-0.440，P < 0.001），而与MMP-9无相关性。在探索性生存分析中，我们发现在局限性疾病患者中，正常或肿瘤组织中的RECK水平与总生存率有显著相关性（P = 0.017）。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
mRNA, and latent and active levels MMP-2 and -9 were higher in tumor tissue compared to normal tissue from 63 patients with colorectal cancer, whereas RECK and EMMPRIN levels were lower. Correlations between mRNA, latent, and active MMP were particular high for MMP-2 in tumor tissue (R-8 = 0.6-0.8. P < 0.001). For active MMP-2, but not for MMP-9, a significant negative partial correlation (R-p = -0.440, P < 0.001) for RECK was found in tumor tissue, which was confirmed by linear regression analysis. In exploratory survival analyses we found that in patients with localized disease the RECK level in normal or tumor tissue had a significant (P = 0.017) association with overall survival. (c) 2005 Elsevier Ireland Ltd. All rights reserved.