Effect of Personal Exposure to PM2.5 on Respiratory Health in a Mexican Panel of Patients with COPD.
Effect of Personal Exposure to PM2.5 on Respiratory Health in a Mexican Panel of Patients with COPD.
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DOI：
10.3390/ijerph120910635
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发表时间：
2015-08-28
影响因子：
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通讯作者：
Barraza-Villarreal A
中科院分区：
文献类型：
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作者：
Cortez-Lugo M;Ramírez-Aguilar M;Pérez-Padilla R;Sansores-Martínez R;Ramírez-Venegas A;Barraza-Villarreal A
背景：空气污染是一个问题，特别是在发展中国家。我们在一组患有慢性阻塞性肺疾病（COPD）的成年人中研究了空气动力学直径小于2.5 µm（PM2.5）的颗粒物的个人暴露与呼吸健康之间的关系。研究方法：所有参与者都居住在墨西哥城，在随访期间，每天记录个人暴露于PM2.5，呼吸道症状，药物和日常活动。从2000年2月至12月，在29名患有中度、重度和极重度COPD的成人中，每天测量两次呼气峰流速（PEF）。每增加10 µg/m3的PM2.5，根据COPD的严重程度、最低温度和采样日期进行调整，估计PEF变化。结果如下：两天个人接触PM2.5的日平均值增加10微克/立方米，咳嗽的发生率显著增加33（95%CI，范围，5 - 69%），痰中为23%（95% CI，范围，2 - 54%），早晨PEF平均值降低-1.4 L/min。（95%CI，范围：-2.8至-0.04）和夜间分别为-3.0 L/min（95%CI，范围：-5.7至-0.3）。结论：暴露于PM2.5与COPD成人患者的PEF降低和呼吸道症状增加相关。在早晨和夜间均观察到PEF降低。
Background: Air pollution is a problem, especially in developing countries. We examined the association between personal exposure to particulate matter with an aerodynamic diameter less than 2.5 µm (PM2.5) on respiratory health in a group of adults with chronic obstructive pulmonary disease (COPD). Methods: All participants resided in Mexico City and during follow-up, personal exposure to PM2.5, respiratory symptoms, medications, and daily activity were registered daily. Peak expiratory flow (PEF) was measured twice daily, from February through December, 2000, in 29 adults with moderate, severe, and very severe COPD. PEF changes were estimated for each 10 µg/m3 increment of PM2.5, adjustment for severity of COPD, minimum temperature, and day of the sampling. Results: For a 10-µg/m3 increase in the daily average of a two-day personal exposure to PM2.5, there was a significant 33% increase in cough (95% CI, range, 5‒69%), and 23% in phlegm (95% CI, range, 2‒54%), a reduction of the PEF average in the morning of −1.4 L/min. (95% CI , range, −2.8 to −0.04), and at night of −3.0 L/min (95% CI, range, −5.7 to −0.3), respectively. Conclusions: Exposure to PM2.5 was associated with reductions in PEF and increased respiratory symptoms in adults with COPD. The PEF reduction was observed both at morning and at night.