Glutamate-dopamine in vivo interaction in the prefrontal cortex modulates the release of dopamine and acetylcholine in the nucleus accumbens of the awake rat
Glutamate-dopamine in vivo interaction in the prefrontal cortex modulates the release of dopamine and acetylcholine in the nucleus accumbens of the awake rat
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DOI：
10.1007/s00702-004-0172-5
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发表时间：
2005-01-01
影响因子：
3.3
通讯作者：
Mora, F
中科院分区：
文献类型：
--
作者：
del Arco, A;Mora, F
在体内神经化学文献的背景下，本文回顾了我们实验室最近关于前额皮质 (PFC) 中谷氨酸-多巴胺相互作用的一些微透析研究及其在调节伏隔核中多巴胺和乙酰胆碱释放中的可能作用。微透析研究报道了 PFC 中的功能性谷氨酸-多巴胺相互作用，表明刺激和阻断前额叶谷氨酸受体都会导致大脑该区域多巴胺的基础和/或刺激释放发生变化。这些研究表明，PFC 中的多巴胺功能受到前额叶谷氨酸能输入的局部调节，并且谷氨酸和多巴胺可以同时调节 PFC 中 GABA 的释放。特别是，多巴胺可以增强通过刺激前额谷氨酸受体而产生的细胞外GABA的增加。我们还报道，前额叶 D2 和 mGlul 受体的刺激及其相互作用改变了伏隔核中多巴胺和乙酰胆碱的释放。
In the context of the in vivo neurochemical literature this article reviews some recent microdialysis studies in our laboratory of glutamate-dopamine interaction in the prefrontal cortex (PFC) and its possible role in modulating dopamine and acetylcholine release in the nucleus accumbens. A functional glutamate-dopamine interaction in PFC has been reported by microdialysis studies showing that both stimulation and blockade of prefrontal glutamate receptors produce changes of basal and/or stimulated release of dopamine in this area of the brain. These studies suggest that dopamine function in PFC is modulated locally by prefrontal glutamatergic inputs and that glutamate and dopamine can act simultaneously to regulate GABA release in PFC. In particular, dopamine can enhance the increases of extracellular GABA produced by the stimulation of prefrontal glutamate receptors. We report also that the stimulation of prefrontal D2 and mGlul receptors and their interaction changes the release of dopamine and acetylcholine in the nucleus accumbens.