Oral clonidine-an effective growth hormone-releasing agent in prepubertal subjects.
Oral clonidine-an effective growth hormone-releasing agent in prepubertal subjects.
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口服可乐定——一种对青春期前受试者有效的生长激素释放剂。
DOI：
10.1016/s0022-3476(82)80569-6
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
E. Hurtado
中科院分区：
文献类型：
--
作者：
R. Lanes;E. Hurtado
评价可乐定、甲氧氯普胺和胰岛素对17名健康青春期前矮小儿童（A组）和5名青春期前生长激素缺乏儿童（B组）血液中生长激素、皮质醇和葡萄糖浓度的影响。胰岛素和可乐定治疗后血清生长激素峰值明显高于胃复安治疗后。在B组患者中，这三种刺激中的任何一种刺激的生长激素值均未高于基线值。血浆皮质醇浓度与甲氧氯普胺没有变化，但与胰岛素显着增加，可乐定后显着下降，可乐定或甲氧氯普胺没有发现葡萄糖值的变化。可乐定似乎是一个可靠的，敏感的，和安全的门诊刺激试验的生长激素储备青春期前的儿童，而甲氧氯普胺似乎不是一个合适的生长激素释放剂在这个年龄组。
The effects of clonidine, metoclopramide, and insulin on growth hormone, cortisol, and glucose concentrations in the blood of 17 healthy prepubertal short children (Group A) and five prepubertal growth hormone-deficient children (Group B) were evaluated. The peak serum growth hormone values after insulin and clonidine were significantly higher than after metoclopramide administration. Growth hormone values did not rise above baseline values in Group B patients with any of these three stimuli. Plasma cortisol concentrations did not change with metoclopramide but increased significantly with insulin and decreased significantly after clonidine; no changes in glucose values were noted with either clonidine or metoclopramide. Clonidine appears to be a reliable, sensitive, and safe out-patient stimulation test of growth hormone reserve in prepubertal children, whereas metoclopramide seems not to be a suitable growth hormone-releasing agent in this age group.