Homodecoupled 1,1- and 1,n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine.
Homodecoupled 1,1- and 1,n-ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine.
复制标题
DOI：
10.1002/anie.201502540
复制
发表时间：
2015-08-24
期刊：
影响因子：
--
通讯作者：
Martin, Gary E
中科院分区：
文献类型：
--
作者：
Sauri, Josep;Bermel, Wolfgang;Martin, Gary E
隐螺旋体碱是迄今为止发现和鉴定的隐螺旋体碱中结构最复杂的生物碱。在最初的报告提出最初提出的结构的有效性问题十年后，对原始密封核磁共振样品的几种降解物进行了表征。我们现在报告了1,1-和1，n-充足（hd -充足）核磁共振实验的改进，同质解耦变体的发展；利用这些技术对于成功解决与隐螺旋体平相关的长期结构问题至关重要。
Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1- and 1,n-ADEQUATE (HD-ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long-standing structural questions associated with crytospirolepine.