Molecular Bases of Cell-Cell Junctions Stability and Dynamics
Molecular Bases of Cell-Cell Junctions Stability and Dynamics
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DOI：
10.1101/cshperspect.a002998
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发表时间：
2009-11-01
影响因子：
7.2
通讯作者：
Lecuit, Thomas
中科院分区：
文献类型：
--
作者：
Cavey, Matthieu;Lecuit, Thomas
上皮细胞-细胞连接由顶端粘附连接（AJs）形成，其由钙粘蛋白粘附分子以动态方式与皮质肌动蛋白细胞骨架相互作用组成。细胞-细胞连接稳定性和动力学的调节对于维持组织完整性和允许整个发育过程中的组织重塑至关重要。肌动蛋白丝的周转和组织与肌球蛋白II活性一起受到严格控制，以产生驱动AJs组装、维护和重塑的机械力。在这篇综述中，我们将讨论这三个不同的阶段，在细胞-细胞连接的寿命，使用几个发展的背景下，说明机械力是如何产生和传输的交界处，以及它们如何影响的完整性和重塑的细胞-细胞连接。
Epithelial cell-cell junctions are formed by apical adherens junctions (AJs), which are composed of cadherin adhesion molecules interacting in a dynamic way with the cortical actin cytoskeleton. Regulation of cell-cell junction stability and dynamics is crucial to maintain tissue integrity and allow tissue remodeling throughout development. Actin filament turnover and organization are tightly controlled together with myosin-II activity to produce mechanical forces that drive the assembly, maintenance, and remodeling of AJs. In this review, we will discuss these three distinct stages in the lifespan of cell-cell junctions, using several developmental contexts, which illustrate how mechanical forces are generated and transmitted at junctions, and how they impact on the integrity and the remodeling of cell-cell junctions.