Height, weight, BMI and ovarian cancer survival
Height, weight, BMI and ovarian cancer survival
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DOI：
10.1016/j.ygyno.2012.05.038
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发表时间：
2012-10-01
影响因子：
4.7
通讯作者：
Narod, Steven A.
中科院分区：
文献类型：
--
作者：
Kotsopoulos, Joanne;Moody, Joel R. K.;Narod, Steven A.
目标。卵巢癌是一种高度致命的妇科恶性肿瘤。预后主要基于临床病理特征。人们对包括超重和肥胖在内的可改变因素的作用很感兴趣，尽管迄今为止的数据还没有定论。在此，我们在一项基于人群的大型研究中评估了1423名被诊断为上皮性卵巢癌的女性的体型与卵巢癌生存率之间的关系。通过电话收集有关危险因素和特征的信息。生命状态是通过计算机记录联系和图表审查来确定的。Cox比例风险模型用于估计身高、体重和身体质量指数（BMI）与卵巢癌特异性死亡率之间的风险比（hr）和95%置信区间(o)。在本研究中，诊断前5年的身高、体重和BMI不能显著预测卵巢癌的生存。与体重为50-55 kg的女性相比，体重为100 - 61 kg的女性卵巢癌特异性死亡率的HR为0.91 （95%CI为0.71-1.20）。体重指数>= 30 kg/m(2)的女性HR为18.5-
Objectives. Ovarian cancer is a highly fatal gynecologic malignancy. Prognosis is primarily based on clinicopathologic features. There is interest in the role of modifiable factors including overweight and obesity, although data to date have been inconclusive. Here we evaluate the relationship between body size and ovarian cancer survival among 1423 women diagnosed with epithelial ovarian cancer in a large population-based study.Methods. Information on risk factors and characteristics was collected by telephone. Vital status was determined both by computerized record-linkage and by chart review. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (Os) for height, weight and body mass index (BMI) in association with ovarian cancer-specific mortality.Results. Height, weight and BMI 5 years prior to diagnosis did not significantly predict ovarian cancer survival in this study. The HR for ovarian cancer-specific mortality for women with a weight of >61 kg compared with > 50-55 kg was 0.91 (95%CI 0.71-1.20). The HR among women with a BMI >= 30 kg/m(2) compared to 18.5-