The Brain Circuits and Dynamics of Curiosity-Driven Behavior in Naturally Curious Marmosets.
The Brain Circuits and Dynamics of Curiosity-Driven Behavior in Naturally Curious Marmosets.
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天生好奇的狨猴的大脑回路和好奇心驱动行为的动力学。
DOI：
10.1093/cercor/bhab080
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Liu,Cirong
中科院分区：
文献类型：
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作者：
Tian,Xiaoguang;Silva,AfonsoC;Liu,Cirong
好奇心是动物适应不断变化的环境的基本天性，但其潜在的大脑回路和机制仍然知之甚少。一个主要障碍是现有研究使用奖励来训练动物并激励它们参与行为任务。因此，奖励成为解释好奇心的重要混杂因素。在这里，我们通过研究幼稚且天生好奇的狨猴克服了这个问题，这些狨猴可以在没有外部奖励的情况下主动、持续地参与视觉选择任务。在执行任务时，狨猴表现出对获取新信息的强烈天生偏好，这与更快的行为反应相关。纵向功能磁共振成像揭示了与行为相关的大脑状态，这些状态反映了选择偏好并涉及多个大脑区域，包括小脑、海马体和皮质区域 19DI、25 和 46D，其中小脑最为突出。这些结果揭示了好奇心驱动活动背后的基本大脑回路和动力学。
Curiosity is a fundamental nature of animals for adapting to changing environments, but its underlying brain circuits and mechanisms remain poorly understood. One main barrier is that existing studies use rewards to train animals and motivate their engagement in behavioral tasks. As such, the rewards become significant confounders in interpreting curiosity. Here, we overcame this problem by studying research-naïve and naturally curious marmosets that can proactively and persistently participate in a visual choice task without external rewards. When performing the task, the marmosets manifested a strong innate preference towards acquiring new information, associated with faster behavioral responses. Longitudinally functional magnetic resonance imaging revealed behavior-relevant brain states that reflected choice preferences and engaged several brain regions, including the cerebellum, the hippocampus, and cortical areas 19DI, 25, and 46D, with the cerebellum being the most prominent. These results unveil the essential brain circuits and dynamics underlying curiosity-driven activity.