Seasonal Trivalent Inactivated Influenza Vaccine Does Not Protect against Newly Emerging Variants of Influenza A (H3N2v) Virus in Ferrets
Seasonal Trivalent Inactivated Influenza Vaccine Does Not Protect against Newly Emerging Variants of Influenza A (H3N2v) Virus in Ferrets
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DOI：
10.1128/jvi.02625-12
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发表时间：
2013-01-01
影响因子：
5.4
通讯作者：
Tumpey, Terrence M.
中科院分区：
文献类型：
--
作者：
Houser, Katherine V.;Katz, Jacqueline M.;Tumpey, Terrence M.
最近人类感染甲型流感H3 N2变异病毒[A（H3 N2）v]病例的增加突出表明，需要评估季节性流感疫苗接种是否能提供针对A（H3 N2）v病毒的交叉保护。我们的数据表明，2011-2012年三价灭活流感疫苗（TIV）保护雪貂免受同源H3 N2病毒攻击，但对A（H3 N2）v病毒提供最低限度的保护。完全不存在对A（H3 N2）v的特异性血凝抑制抗体反应与在TIV免疫动物中观察到的不良交叉保护一致。
The recent increase in human cases of influenza A H3N2 variant virus [A(H3N2)v] highlights the need to assess whether seasonal influenza vaccination provides cross-protection against A(H3N2) v virus. Our data demonstrate that the 2011-2012 trivalent inactivated influenza vaccine (TIV) protected ferrets against homologous H3N2 virus challenge but provided minimal to no protection against A(H3N2) v virus. The complete absence of specific hemagglutination inhibition antibody response to A(H3N2) v is consistent with the poor cross-protection observed among TIV-immune animals.