Nonspecific (Heterologous) Protection of Neonatal BCG Vaccination Against Hospitalization Due to Respiratory Infection and Sepsis
Nonspecific (Heterologous) Protection of Neonatal BCG Vaccination Against Hospitalization Due to Respiratory Infection and Sepsis
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DOI：
10.1093/cid/civ144
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发表时间：
2015-06-01
影响因子：
11.8
通讯作者：
Martinon-Torres, Federico
中科院分区：
文献类型：
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作者：
Jose de Castro, Maria;Pardo-Seco, Jacobo;Martinon-Torres, Federico
背景资料。卡介苗(BCG)接种卡介苗对发展中国家的儿童有非特异性的益处，可降低由无关病原体引起的发病率和死亡率。我们的目的是评估卡介苗接种对西班牙出生的儿童中非结核病引起的呼吸道感染(RI)和败血症的异种保护作用。我们利用西班牙官方住院登记处(CMBD-HA)的数据进行了一项回顾性流行病学研究，以确定接种卡介苗的儿童(巴斯克地区，新生儿卡介苗是免疫计划的一部分，覆盖率为100%)与未接种卡介苗的儿童(来自西班牙其他地区，不使用卡介苗)的住院率(HR)差异。对1992~2011年的464 611例住院病例进行了分析。在所有年龄组中，接种卡介苗的儿童由于非结核病引起的RI引起的HR显著低于未接种卡介苗的儿童，总预防分数(PF)为41.4%(95%可信区间：40.3-42.5；P值
Background. Bacille Calmette-Guerin (BCG) vaccination has been suggested to have nonspecific beneficial effects in children from developing countries, reducing morbidity and mortality caused by unrelated pathogens.Objective. We aimed to assess the heterologous protective effects of BCG vaccination against respiratory infection (RI) and sepsis not attributable to tuberculosis in children born in Spain.Methods. We conducted a retrospective epidemiological study using data from the Official Spanish Registry of Hospitalizations (CMBD-HA) to identify differences in hospitalization rates (HR) in BCG-vaccinated children (Basque Country, where neonatal BCG is part of the immunization schedule and has a 100% coverage) as compared to non-BCG-vaccinated children (from the rest of Spain, where BCG is not used).Results. A total of 464 611 hospitalization episodes from 1992 to 2011 were analyzed. The HR due to RI not attributable to tuberculosis in BCG-vaccinated children was significant lower compared to non-BCG-vaccinated children for all age groups, with a total preventive fraction (PF) of 41.4% (95% confidence interval: 40.3-42.5; P-value