Functional Impairment Is Associated With Low Bone and Muscle Mass Among Persons Aging With HIV Infection
Functional Impairment Is Associated With Low Bone and Muscle Mass Among Persons Aging With HIV Infection
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DOI：
10.1097/qai.0b013e318289bb7e
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发表时间：
2013-06-01
影响因子：
3.6
通讯作者：
Campbell, Thomas B.
中科院分区：
文献类型：
--
作者：
Erlandson, Kristine M.;Allshouse, Amanda A.;Campbell, Thomas B.
背景：残疾和虚弱与骨质疏松症、肥胖症和肌肉减少症有关。 HIV感染者有早期功能障碍，但身体成分与功能障碍之间的关联尚不清楚。方法：接受抗逆转录病毒治疗与病毒学抑制联合治疗的HIV-1感染者，年龄为45-65岁，具有标准化的身体功能测量。在一项嵌套分析中，30 名低功能病例和 48 名高功能病例和对照按年龄、性别和艾滋病毒诊断后的时间进行了匹配。通过双能 X 射线吸收测定法评估骨矿物质密度、脂肪量和去脂体重。通过条件逻辑回归获得95%置信区间的比值比(OR)。结果：平均年龄为53岁，平均CD4(+)淋巴细胞每微升598个细胞，96%的人血浆中有HIV-1 RNA，每毫升50个拷贝。低功能和高功能受试者的CD4(+)淋巴细胞计数、抗逆转录病毒治疗的持续时间和类型相似。较低的髋部 T 评分 [OR：3.8（1.1 至 12.5）] 和腰椎 [OR：2.3（1.1 至 4.5）] 和较低的去脂体重 [OR：1.1（1.0 至 1.2）] 与低功能的几率显着增加相关（P
Background: Disability and frailty are associated with osteoporosis, obesity, and sarcopenia. HIV-infected persons have early functional impairment, but the association between body composition and functional impairment is unknown.Methods: HIV-1-infected participants on combination antiretroviral therapy with virologic suppression, aged 45-65 years, had standardized physical function measures. In a nested analysis, 30 low- and 48 high-functioning cases and controls were matched by age, gender, and time since HIV diagnosis. Bone mineral density, fat mass, and lean body mass were assessed by dual-energy x-ray absorptiometry. Odds ratios (ORs) with 95% confidence intervals were obtained from conditional logistic regression.Results: Mean age was 53 years, mean CD4(+) lymphocytes 598 cells per microliter, and 96% had plasma HIV-1 RNA,50 copies per milliliter. Low- and high-function subjects had similar CD4(+) lymphocyte count and duration and type of antiretroviral therapy. Lower T scores at the hip [OR: 3.8 (1.1 to 12.5)] and lumbar spine [OR: 2.3 (1.1 to 4.5)] and lower lean body mass [OR: 1.1 (1.0 to 1.2)] were associated with significantly greater odds of low function (P