Extracellular transglutaminase 2 activates β-catenin signaling in calcifying vascular smooth muscle cells
Extracellular transglutaminase 2 activates β-catenin signaling in calcifying vascular smooth muscle cells
复制标题
DOI：
10.1016/j.febslet.2008.03.053
复制
发表时间：
2008-04-30
期刊：
影响因子：
3.5
通讯作者：
Nurminskaya, Maria
中科院分区：
文献类型：
--
作者：
Faverman, Lidia;Mikhaylova, Lyudmila;Nurminskaya, Maria
转氨酶2（TG 2）的蓄积通常与脉管系统中的矿物质沉积有关。在这里，我们证明，纯化的TG 2刺激3倍增加基质矿化和成骨细胞标记物在培养的原代血管平滑肌细胞（VSMCs）的上调。细胞外TG 2与低密度脂蛋白相关蛋白5受体相互作用并激活VSMC中的β-连环蛋白信号传导。这些结果表明，TG 2可能通过激活β-连环蛋白信号通路促进血管钙化。(C)2008年由Elsevier B. V.代表欧洲生物化学学会联合会出版。
Accumulation of transglutaminase 2 (TG2) is often associated with mineral deposits in vasculature. Here, we demonstrate that purified TG2 stimulated a 3-fold increase in matrix mineralization and up-regulation of osteoblastic markers in cultured primary vascular smooth muscle cells (VSMCs). Extracellular TG2 interacts with the low density lipoprotein related-protein 5 receptor and activates beta-catenin signaling in VSMCs. These results suggest that TG2 may promote vascular calcification by activating the beta-catenin signaling pathway. (C) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.