Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts Male Aging Study
Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts Male Aging Study
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中年男性血清睾酮和其他激素水平的年龄趋势：马萨诸塞州男性衰老研究的纵向结果
DOI：
10.1210/jc.87.2.589
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发表时间：
2002-02-01
影响因子：
5.8
通讯作者：
McKinlay, JB
中科院分区：
文献类型：
--
作者：
Feldman, HA;Longcope, C;McKinlay, JB
我们使用了马萨诸塞州男性老龄化研究的纵向数据，这是一个以人口为基础的大型随机样本队列，年龄为40-70岁的男性基线，以建立中年男性血清T和相关激素水平的标准年龄趋势，并测试总体健康状况是否影响年龄趋势。在1987-1989年间招募的1709名男性中，有1156人在7-10年后进行了随访。通过重复测量统计分析，我们同时估计了基线数据内受试者之间每种激素的横截面年龄趋势，随访数据内受试者之间的横截面趋势，以及受试者内基线和随访之间的纵向趋势。总T在随访数据中以0.8%/年的速度横向下降，而游离和白蛋白结合的T以大约2%/年的速度下降，均显著高于基线数据内的下降幅度。在随访数据中，性激素结合球蛋白以每年1.6%的速度横向增加，与基线相似。受试者在基线和随访之间的纵向下降比测量时间内总T(1.6%/年)和生物有效T(2-3%/年)的横截面趋势要陡峭得多。脱氢表雄酮、脱氢表雄酮硫酸盐、皮质醇和雌酮呈纵向显著下降，而双氢睾酮、垂体促性腺激素和催乳素纵向上升。明显的健康状况，定义为没有慢性病、没有处方药物、肥胖或过度饮酒，使几种雄激素水平增加了10%-15%，并减弱了睾酮和黄体生成素的横向趋势，但不影响纵向或横向趋势。矛盾的发现是纵向年龄趋势比横向趋势陡峭，这一矛盾的发现表明，健康状况不佳可能加速与年龄相关的雄激素水平下降。
We used longitudinal data from the Massachusetts Male Aging Study, a large population-based random-sample cohort of men aged 40-70 yr at baseline, to establish normative age trends for serum level of T and related hormones in middle-aged men and to test whether general health status affected the age trends. Of 1,709 men enrolled in 1987-1989,1,156 were followed up 7-10 yr afterward. By repeated-measures statistical analysis, we estimated simultaneously the cross-sectional age trend of each hormone between subjects within the baseline data, the cross-sectional trend between subjects within the follow-up data, and the longitudinal trend within subjects between baseline and follow-up.Total T declined cross-sectionally at 0.8%/yr of age within the follow-up data, whereas both free and albumin-bound T declined at about 2%/yr, all significantly more steeply than within the baseline data. Sex hormone-binding globulin increased cross-sectionally at 1.6%/yr in the follow-up data, similarly to baseline. The longitudinal decline within subjects between baseline and follow-up was considerably steeper than the cross-sectional trend within measurement times for total T (1.6%/yr) and bioavailable T (2-3%/yr). Dehydroepiandrosterone, dehydroepiandrosterone sulfate, cortisol, and estrone showed significant longitudinal declines, whereas dihydrotestosterone, pituitary gonadotropins, and PRL rose longitudinally.Apparent good health, defined as absence of chronic illness, prescription medication, obesity, or excessive drinking, added 10-15% to the level of several androgens and attenuated the cross-sectional trends in T and LH but did not otherwise affect longitudinal or cross-sectional trends.The paradoxical finding that longitudinal age trends were steeper than cross-sectional trends suggests that incident poor health may accelerate the age-related decline in androgen levels.