Gestational Diabetes Independently Increases Birth Length and Augments the Effects of Maternal BMI on Birth Weight: A Retrospective Cohort Study.
Gestational Diabetes Independently Increases Birth Length and Augments the Effects of Maternal BMI on Birth Weight: A Retrospective Cohort Study.
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DOI：
10.3389/fped.2014.00112
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发表时间：
2014
影响因子：
2.6
通讯作者：
Nanan RK
中科院分区：
文献类型：
--
作者：
Byström M;Liu A;Quinton AE;Champion BL;Mann K;Peek M;Nanan RK
目的：探讨妊娠期糖尿病（GDM）与母亲体重指数（BMI）的交互作用对新生儿个体生长参数的影响。设计：回顾性队列研究。背景：2005年至2009年期间，澳大利亚悉尼的一家三级产科服务机构。人群：8859名女性。方法：广义线性模型。主要结局指标：新生儿生长参数，以GDM和非GDM组中婴儿出生体重（BW）、出生身长（BL）和头围（HC）的z评分表示。结果：仅GDM单独对BL有独立的正效应（p = 0.02），但对BW或HC无影响。此外，在妊娠合并GDM的孕妇中，母体体重与BW之间的关联性显著更强（p < 0.001）。综合来看，GDM和母亲BMI显著影响BW和BL之间的z评分差异（p < 0.001），因为体重不足的母亲的婴儿相对于其长度较轻，而肥胖的母亲的婴儿相对于其长度较重。结论：GDM独立影响BL，并增加母亲BMI与BW之间的关联。根据健康和疾病的胎儿起源的假设，在这项研究中证明，GDM对胎儿生长模式的显着影响可能会影响儿童的长期健康结果。
Objective: To investigate the effect of the interaction between gestational diabetes mellitus (GDM) and maternal body mass index (BMI) on the individual neonatal growth parameters. Design: Retrospective cohort study. Setting: A tertiary maternity service in Sydney, Australia, between 2005 and 2009. Population: A cohort of 8859 women. Methods: Generalized linear models. Main outcome measures: Neonatal growth parameters, represented by z-scores for infant birth weight (BW), birth length (BL), and head circumference (HC) in GDM and non-GDM groups. Results: Only GDM alone had an independent and positive effect on BL (p = 0.02) but not on BW or HC. In addition, in pregnancies complicated with GDM, the association between maternal weight and BW was significantly stronger (p < 0.001). In combination, GDM and maternal BMI significantly affected z-score differences between BW and BL (p < 0.001), in that underweight mothers had babies that were lighter relative to their length and inversely obese mothers had babies that were heavier relative to their length. Conclusion: GDM independently influences BL and increases the association between maternal BMI and BW. In accordance with the hypothesis of the fetal origins of health and disease, the pronounced effects of GDM on fetal growth patterns demonstrated in this study are likely to influence long-term health outcomes in children.
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影响因子：
9.8
作者：
Catalano PM;Hauguel-De Mouzon S
通讯作者：
Hauguel-De Mouzon S
DOI：
10.1016/j.beem.2010.05.006
发表时间：
2010-08-01
影响因子：
7.4
作者：
Herrera, Emilio;Ortega-Senovilla, Henar
通讯作者：
Ortega-Senovilla, Henar
影响因子：
3.8
作者：
Jansson, T.;Cetin, I.;Sibley, C. P.
通讯作者：
Sibley, C. P.
DOI：
10.1111/j.1471-0528.2009.02486.x
发表时间：
2010-04-01
影响因子：
5.8
作者：
Metzger, B. E.
通讯作者：
Metzger, B. E.
DOI：
10.1111/j.1479-828x.2010.01218.x
发表时间：
2010-10-01
影响因子：
1.7
作者：
Flack, Jeff R.;Ross, Glynis P.;McElduff, Aidan
通讯作者：
McElduff, Aidan