Risk factors for the local recurrence of hepatocellular carcinoma after a single session of percutaneous radiofrequency ablation
Risk factors for the local recurrence of hepatocellular carcinoma after a single session of percutaneous radiofrequency ablation
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DOI：
10.1007/s00535-003-1181-0
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发表时间：
2003-10-01
影响因子：
6.3
通讯作者：
Tsubouchi, H
中科院分区：
文献类型：
--
作者：
Hori, T;Nagata, K;Tsubouchi, H
背景射频消融（RFA）是一种新的、微创的治疗肝细胞癌（HCC）的方法。然而，关于单次电极插入的单次RFA治疗后局部复发的可用信息很少。方法.从1999年2月到2001年9月，我们用带四个钩的可膨胀针治疗了104个HCC肿瘤。104个肿瘤中有99个通过单次射频消融成功治疗，并插入一个电极。我们研究了这99例肿瘤的预处理因素（肿瘤大小、肿瘤染色、肿瘤包膜和肿瘤位置）与局部复发的关系。结果99个肿瘤的平均直径为21.5 mm（范围，10 - 33 mm）。1年、2年和3年的总体局部复发率分别为9.7%、15.4%和20.4%。对于小肿瘤（小于25 mm），1年、2年和3年的局部复发率为4.0%。8.0%和14.6%。对于较大的肿瘤（25 mm或更大），1年和2年的局部复发率分别为21.1%和32.3%，3年时，靠近肝表面的肿瘤复发率超过50%。肿瘤大小和肿瘤相对于肝脏表面的位置与较高的局部复发率显著相关。然而，其他变量的测试显示没有显着的关系，局部复发率。结论.该研究表明，肿瘤大小和相对于肝脏表面的位置都会影响单次电极插入的单次RFA的局部疗效。
Background Radiofrequency ablation (RFA) is a new, minimally invasive treatment for hepatocellular carcinoma (HCC). However, there is little available information regarding, local recurrence after a sin le session of RFA with a single electrode insertion. Methods. From February 1999 to September 2001, we treated 104 HCC tumors with an expandable needle with four hooks. Ninety-nine of the 104 tumors were successfully treated by single-session RFA with a single electrode insertion. We investigated the relationships between pretreatment factors (tumor size, tumor staining, tumor capsule, and tumor location) and local recurrence in these 99 tumors. Results. The mean size of the 99 tumors was 21.5 mm in diameter (range, 10 to 33 mm). The overall local recurrence rates were 9.7%, 15.4%, and 20.4%, at 1, 2, and 3 years, respectively. For small tumors (smaller than 25 mm), the local recurrence rates at 1, 2, and 3 years were 4.0%. 8.0%, and 14.6%, respectively. The local recurrence rates were 21.1% and 32.3% at 1 and 2 years, respectively, for large tumors (25 mm or larger), and at 3 years the rate was over 50% for tumors located close to the liver surface. Tumor size and tumor location relative to the liver surface were significantly associated with a higher local recurrence rate. However, other variables tested showed no significant relationship to the local recurrence rate. Conclusions. This study demonstrated that both tumor size and location relative to the liver surface influence the local efficacy of single-session RFA with a single electrode insertion.