Epigenetic regulation of endothelial-cell-mediated vascular repair
Epigenetic regulation of endothelial-cell-mediated vascular repair
复制标题
DOI：
10.1111/febs.13183
复制
发表时间：
2015-05-01
期刊：
影响因子：
5.4
通讯作者：
Brand, Marjorie
中科院分区：
文献类型：
--
作者：
Fraineau, Sylvain;Palii, Carmen G.;Brand, Marjorie
维持血管完整性对于预防血管疾病和在心血管、脑血管和外周血管事件（包括肢体缺血、心脏病发作和中风）之后的恢复是必不可少的。内皮干/祖细胞由于其在干细胞治疗中介导缺血性损伤后血管再生的潜在用途，最近获得了相当大的兴趣。因此，迫切需要了解在特定细胞类型中调节血管修复的基本机制，以开发新的有益的治疗干预措施。在这篇综述中，我们强调了最近的研究表明，表观遗传机制（包括DNA和组蛋白的翻译后修饰以及非编码RNA介导的过程）通过修饰染色质结构在内皮干/祖细胞功能的调节中发挥着至关重要的作用。此外，我们还讨论了使用调节表观遗传酶活性的小分子来增强内皮细胞的血管修复功能的潜力，并提供了可能加速临床应用的潜在策略的见解。
Maintenance of vascular integrity is essential for the prevention of vascular disease and for recovery following cardiovascular, cerebrovascular and peripheral vascular events including limb ischemia, heart attack and stroke. Endothelial stem/progenitor cells have recently gained considerable interest due to their potential use in stem cell therapies to mediate revascularization after ischemic injury. Therefore, there is an urgent need to understand fundamental mechanisms regulating vascular repair in specific cell types to develop new beneficial therapeutic interventions. In this review, we highlight recent studies demonstrating that epigenetic mechanisms (including post-translational modifications of DNA and histones as well as non-coding RNA-mediated processes) play essential roles in the regulation of endothelial stem/progenitor cell functions through modifying chromatin structure. Furthermore, we discuss the potential of using small molecules that modulate the activities of epigenetic enzymes to enhance the vascular repair function of endothelial cells and offer insight on potential strategies that may accelerate clinical applications.