Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A
Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A
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根据天然脂质 A 的修订结构模型合成的免疫生物学活性脂质 A 类似物
DOI：
10.1128/iai.45.1.293-296.1984
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发表时间：
1984
影响因子：
3.1
通讯作者：
S. Tanaka
中科院分区：
文献类型：
--
作者：
S. Kotani;H. Takada;M. Tsujimoto;T. Ogawa;K. Harada;Y. Mori;A. Kawasaki;A. Tanaka;S. Nagao;S. Tanaka
在大多数体外实验中，在β(1-6)氨基葡萄糖二糖单或二磷酸的C-2和-2‘以及C-3和-3’位上含有两个酰胺结合和两个酯结合的(R)-3-羟基十四酰基的合成类脂A在大多数体外试验中显示出较高的活性，二磷酸衍生物对半乳糖胺处理的小鼠的致死率几乎与天然类脂A相当。然而，合成类似物的致热性和Shwartzman诱导活性远低于天然类脂A。
Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate derivative to galactosamine-treated mice was almost comparable to that of natural lipid A. The pyrogenicity and Shwartzman induction activity of the synthetic analogs, however, were much less than those of natural lipid A.
通过碳 13 核磁共振表征大肠杆菌无庚糖突变体的脂多糖。
DOI：
--
发表时间：
1983
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Strain,SM;Fesik,SW;Armitage,IM
通讯作者：
Armitage,IM