Ranibizumab Injection as Primary Treatment in Patients with Retinopathy of Prematurity Anatomic Outcomes and Influencing Factors
Ranibizumab Injection as Primary Treatment in Patients with Retinopathy of Prematurity Anatomic Outcomes and Influencing Factors
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雷珠单抗注射液作为早产儿视网膜病变患者主要治疗的解剖结果及影响因素
DOI：
10.1016/j.ophtha.2017.03.018
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发表时间：
2017-08-01
期刊：
影响因子：
13.7
通讯作者：
Zhao, Peiquan
中科院分区：
文献类型：
--
作者：
Huang, Qiujing;Zhang, Qi;Zhao, Peiquan
目的：探讨雷珠单抗治疗早产儿视网膜病变（ROP）的解剖学结局及影响因素。设计：回顾性病例系列。研究对象：以玻璃体内注射雷珠单抗（IVR）作为主要治疗的 145 例 1 型 ROP 患者，共 283 只眼。方法：对诊断为 1 型 ROP 并接受 IVR（0.25）的婴儿进行回顾性分析。 2012年1月至2015年8月期间以1mg/0.025ml)为主要治疗，分析解剖学结果及影响因素。主要指标：IVR后ROP眼的解剖学结果及影响因素。结果：本研究共纳入145例患者283只眼。 IVR后阳性反应组共有266只眼（94.0%），阴性/无反应组共有17只眼（6.0%）。在阳性反应组中，139只眼（48.6%）属于无再激活消退亚组，127只眼（44.9%）属于有再激活消退亚组。共有 152 只眼睛接受了额外的激光或手术治疗。末次就诊时，278只眼（98.2%）有视网膜附着，5只眼（1.8%）有视网膜脱离。分类树模型显示，对于胎龄 (GA) 29.5 周的患者（61.6% vs. 29.6%）。此外，对于 GA 患者
Purpose: To investigate the anatomic outcomes and influencing factors of ranibizumab in the treatment of retinopathy of prematurity (ROP).Design: Retrospective case series.Participants: A total of 283 eyes of 145 patients with type 1 ROP treated with intravitreal injection of ranibizumab (IVR) as primary treatment.Methods: Retrospective review of infants who were diagnosed with type 1 ROP and accepted IVR (0.25 mg/0.025 ml) as primary treatment from January 2012 to August 2015. The anatomic outcomes and the influencing factors were analyzed.Main Outcome Measures: Anatomic outcomes of ROP eyes after IVR and the influencing factors.Results: A total of 283 eyes of 145 patients were included in this study. There were a total of 266 eyes (94.0%) in the positive response group and 17 eyes (6.0%) in the negative/no response group after IVR. Within the positive response group, 139 eyes (48.6%) were in the regression without reactivation subgroup, and 127 eyes (44.9%) were in the regression with reactivation subgroup. A total of 152 eyes received additional laser or surgical treatment. At the last visit, 278 eyes (98.2%) had attached retinas, and 5 eyes (1.8%) had retinal detachment. A classification tree model showed that for patients with gestational age (GA) 29.5 weeks (61.6% vs. 29.6%). Moreover, for patients with GA