Cognitive dysfunction in systemic lupus erythematosus
Cognitive dysfunction in systemic lupus erythematosus
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DOI：
10.1111/j.1440-1819.2005.01418.x
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发表时间：
2005-10-01
影响因子：
11.9
通讯作者：
Kato, M
中科院分区：
文献类型：
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作者：
Emori, A;Matsushima, E;Kato, M
系统性红斑狼疮（SLE）是一种自身免疫介导的胶原病，导致多器官功能衰竭。它是最常与神经精神症状相关的胶原蛋白疾病，已被假设为源于某些类型的认知功能障碍。受试者为21例在综合医院风湿科接受治疗的SLE患者（1例男性，20例女性;年龄16 - 55岁;平均年龄35.1 ± 10.7岁）和17例年龄和性别与患者组匹配的健康对照受试者（2例男性，15例女性;平均年龄35.9 ± 6.3岁）。他们接受了各种认知功能测试，包括语言推理，非语言推理，语言记忆，非语言记忆，注意力和心理灵活性，心理速度和额叶功能。此外，SLE患者进行抗磷脂抗体检测。SLE患者在Rey言语测验和韦氏记忆量表配对联想测验中的即时、延迟和干扰测验成绩均低于对照组，在Trail A和Trail B测验中的反应时低于对照组。此外，这些发现在具有主要神经精神症状的组中更明显。然而，这些认知功能缺陷与是否存在抗磷脂抗体之间没有明显的关系。结果表明，言语记忆和心理速度的基础上看到的SLE患者的神经精神症状。
Systemic lupus erythematosus (SLE) is an autoimmune-mediated collagen disease that results in multiorgan failure. It is the collagen disease most frequently associated with neuropsychiatric symptoms, which have been hypothesized to stem from certain types of cognitive dysfunction. Subjects were 21 patients with SLE (one man, 20 women; aged 16-55 years; mean age, 35.1 +/- 10.7 years) who were undergoing treatment in the rheumatology unit of a general hospital, and 17 healthy control subjects matched to the patient group with respect to age and gender (two men, 15 women; mean age, 35.9 +/- 6.3 years). They were administered various tests of cognitive function including verbal reasoning, non-verbal reasoning, verbal memory, non-verbal memory, attention and mental flexibility, psychomotor speed and frontal lobe function. In addition, the SLE patients were tested for antiphospholipid antibodies. The SLE patients performed worse than the control group on immediate, delayed and interference of the Rey verbal test and paired associate tests of Wechsler Memory Scale, and their reaction time was slower in Trail A and Trail B tests. Moreover, these findings were more pronounced in the group with major neuropsychiatric symptoms. However, no relationship was apparent between these deficits in cognitive function and the presence or absence of antiphospholipid antibodies. The results suggest that verbal memory and psychomotor speed underlie the neuropsychiatric symptoms seen in SLE patients.