A new rabbit model for keratoconjunctivitis sicca.
A new rabbit model for keratoconjunctivitis sicca.
复制标题
DOI：
--
复制
发表时间：
1987-02
影响因子：
4.4
通讯作者：
J. P. Gilbard;S. R. Rossi;K. Gray
中科院分区：
文献类型：
--
作者：
J. P. Gilbard;S. R. Rossi;K. Gray
作者通过烧灼泪腺排泄管并通过手术切除瞬膜和哈氏腺，创建了一种新的干燥性角结膜炎兔子模型。尽管术后前 8 周裂隙灯检查结果保持正常，但术后第 1 天泪膜渗透压升高。角膜上皮糖原水平逐渐下降，结膜杯状细胞密度仍然下降。多项对照表明，泪膜渗透压升高需要关闭泪腺排泄管，而泪膜渗透压升高又是持续性眼表疾病所必需的。
The authors created a new rabbit model for keratoconjunctivitis sicca by cauterizing the lacrimal gland excretory duct and surgically removing the nictitating membrane and harderian gland. Although the slit-lamp examination findings remained normal for the first 8 wk postoperatively, tear-film osmolarity was elevated by postoperative day 1. Corneal epithelial glycogen levels declined progressively, and conjunctival goblet cell density remained decreased. Multiple controls indicated that closure of the lacrimal gland excretory duct was required for elevation of tear film osmolarity, which, in turn, was required for persistent ocular surface disease.