FUSION OF A KINASE GENE, ALK, TO A NUCLEOLAR PROTEIN GENE, NPM, IN NON-HODGKINS-LYMPHOMA
FUSION OF A KINASE GENE, ALK, TO A NUCLEOLAR PROTEIN GENE, NPM, IN NON-HODGKINS-LYMPHOMA
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DOI：
10.1126/science.8122112
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发表时间：
1994-03-04
期刊：
影响因子：
56.9
通讯作者：
LOOK, AT
中科院分区：
文献类型：
--
作者：
MORRIS, SW;KIRSTEIN, MN;LOOK, AT
2；5染色体易位发生在大多数间变性大细胞非霍奇金淋巴瘤中，这些淋巴瘤是由活化的T淋巴细胞引起的。这种重排被证明将染色体5q35上的NPM核仁磷酸蛋白基因与染色体2p23上先前未知的蛋白酪氨酸激酶基因alk融合在一起。在预测的杂交蛋白中，核磷蛋白(NPM)的氨基末端与间变性淋巴瘤激酶(ALK)的催化结构域相连。ALK在小肠、睾丸和脑中表达，但在正常淋巴细胞中不表达，它与胰岛素受体亚家族的激酶具有最大的序列相似性。截短的ALK的非程序性表达可能有助于这些淋巴瘤的恶性转化。
The 2;5 chromosomal translocation occurs in most anaplastic large-cell non-Hodgkin's lymphomas arising from activated T lymphocytes. This rearrangement was shown to fuse the NPM nucleolar phosphoprotein:gene on chromosome 5q35 to a previously unidentified protein tyrosine kinase gene, ALK, on chromosome 2p23. In the predicted hybrid protein, the amino terminus of nucleophosmin (NPM) is linked to the catalytic domain of anaplastic lymphoma kinase (ALK). Expressed in the small intestine, testis, and brain but not in normal lymphoid cells, ALK shows greatest sequence similarity to the insulin receptor subfamily of kinases. Unscheduled expression of the truncated ALK may contribute to malignant transformation in these lymphomas.