Guidance for contained field trials of vector mosquitoes engineered to contain a gene drive system: Recommendations of a scientific working group
Guidance for contained field trials of vector mosquitoes engineered to contain a gene drive system: Recommendations of a scientific working group
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DOI：
10.1089/vbz.2007.0273
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发表时间：
2008-04-01
影响因子：
2.1
通讯作者：
Toure, Yeya
中科院分区：
文献类型：
--
作者：
Benedict, Mark;D'Abbs, Peter;Toure, Yeya
1.以下建议代表了一组参与的科学家对需要指导以帮助研究人员、政府当局和社区领导人的反应，因为他们考虑设计和实施实地试验以评估减少蚊子媒介传播疾病的遗传策略的安全性和有效性。为基因工程（GE）载体蚊子的封闭（笼中）田间试验提供了指导，所述载体蚊子是可繁殖的并且含有设计成通过天然蚊子种群传播的新型遗传构建体（“基因驱动系统”）。努力提出在进行此类测试之前必须考虑的实际问题，根据现有信息提出一般性建议，并确定可能需要的额外信息的“考虑要点”，以便逐案作出知情决定。本指南旨在阐明进一步评估转基因蚊子作为改善疾病流行地区公共卫生的工具的潜在效用的途径。
1. OBJECTIVETHE FOLLOWING RECOMMENDATIONS represent the response of a group of involved scientists to the need for guidance to aid researchers, government authorities, and community leaders as they consider the design and implementation of field trials to assess the safety and efficacy of genetic strategies for reducing the transmission of diseases by mosquito vectors. Guidance is provided for contained (caged) field trials of genetically-engineered (GE) vector mosquitoes that are fertile and contain novel genetic constructs designed to spread through natural mosquito populations (“gene drive systems”). An effort is made to raise the practical issues that must be considered in advance of such testing, provide generalized recommendations based on currently available information, and identify “points to consider” regarding additional information that may be required in order to make informed decisions on a case-by-case basis. This guidance is intended to clarify the pathway for further assessment of the potential utility of such GE mosquitoes as a tool for the improvement of public health in disease-endemic regions.