Congener-specific body burden levels and possible determinants of polybrominated diphenyl ethers in the general Japanese population.
Congener-specific body burden levels and possible determinants of polybrominated diphenyl ethers in the general Japanese population.
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DOI：
10.1016/j.chemosphere.2010.02.050
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发表时间：
2010-04
期刊：
影响因子：
8.8
通讯作者：
H. Uemura;K. Arisawa;M. Hiyoshi;Satoru Dakeshita;Atsushi Kitayama;Hidenobu Takami;Fusakazu Sawachika;Miwa Yamaguchi;Shuhei Sasai
中科院分区：
文献类型：
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作者：
H. Uemura;K. Arisawa;M. Hiyoshi;Satoru Dakeshita;Atsushi Kitayama;Hidenobu Takami;Fusakazu Sawachika;Miwa Yamaguchi;Shuhei Sasai
CAPTIVEOUR的目标是调查特定的身体负担水平和可能的决定因素的多溴联苯醚（PBDEs）在日本human population.METHODSWe进行了一项横断面研究，72名参与者年龄在15- 74岁;受试者没有职业暴露于PBDEs或二恶英样多氯联苯（DL-PCBs）。参加者居住在两个城市地区和两个渔村。27 PBDE同系物，PCB-126，PCB-118，PCB-156和生化因子测定空腹血液。14种同系物中超过一半的多溴二苯醚含量低于检出限。多溴二苯醚总浓度的中位数为3.6ngg− 1脂质。最丰富的同类物是BDE-209（中位浓度，0.90ngg-1 lipid），其次是BDE-153、BDE-207和BDE-47（按给定顺序）。大多数溴原子数为106的多溴二苯醚同系物与三种DL-多氯联苯的浓度（表明接触途径相同）以及与二十碳五烯酸和二十二碳六烯酸（鱼类摄入量的生物标志物）的血浆浓度存在显著的正相关。在调整年龄、性别和体重指数（log）后，这些相关性没有实质性变化。这些积极的协会与DL-PCB或EPA/DHA的浓度没有发现在分析中的高溴化的PBDE同系物与1008溴atomis.CONCLUSIONSFish消费可能是一个主要的贡献者与1006溴原子之间的一般日本人口的PBDE同系物的积累。相比之下，人类接触高溴多溴二苯醚的主要途径可能与食用鱼类无关。
OBJECTIVEOur objective was to investigate congener-specific body burden levels and possible determinants of polybrominated diphenyl ethers (PBDEs) in the Japanese human population.METHODSWe conducted a cross-sectional study on 72 participants aged 15–74years; subjects were not occupationally exposed to PBDEs or dioxin-like polychlorinated biphenyls (DL–PCBs). Participants lived in two urban areas and two fishing villages. Twenty-seven PBDE congeners, PCB-126, PCB-118, PCB-156, and biochemical factors were determined in fasting blood. A questionnaire survey on life-style was also conducted.RESULTSMore than half of the PBDE values for 14 congeners were below the levels of detection (LODs). The median concentration of total PBDEs was 3.6ngg−1lipid. The most abundant congener was BDE-209 (median concentration, 0.90ngg−1lipid), followed by BDE-153, BDE-207, and BDE-47 in the given order. Most PBDE congeners with⩽6 bromine atoms had significant positive associations with the concentrations of the three DL–PCBs (suggesting common routes of exposure) and with plasma concentrations of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), biological markers of fish intake. These associations did not change substantially after adjustment for age, sex, and log(body mass index). These positive associations with the concentrations of DL–PCBs or EPA/DHA were not found in analyses of high-brominated PBDE congeners with ⩾8 bromine atoms.CONCLUSIONSFish consumption may be a major contributor to the accumulation of PBDE congeners with ⩽6 bromine atoms among the general Japanese population. In contrast, the main exposure routes to high-brominated PBDEs in humans are probably not associated with fish consumption.