Natural history of multiple sclerosis in a population-based cohort
Natural history of multiple sclerosis in a population-based cohort
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DOI：
10.1111/j.1468-1331.2008.02241.x
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发表时间：
2008-09-01
影响因子：
5.1
通讯作者：
Guillemin, F.
中科院分区：
文献类型：
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作者：
Debouverie, M.;Pittion-Vouyovitch, S.;Guillemin, F.
我们试图确定多发性硬化症 (MS) 患者初始病程中残疾的预测性临床因素。对来自 LORSEP（洛林多发性硬化症）人群队列的总共 2871 名 MS 患者进行了分析。使用 Cox 回归模型评估基线人口统计学、临床预测因子和扩展残疾状态量表 (EDSS) 评分为 3、4 和 6 分的时间之间的关系。多变量分析表明，对于复发缓解型患者，获得 EDSS 评分为 4 分的时间较短与 MS 发病年龄较大和首次复发后恢复不完全相关。中位时间不受性别或前两次复发之间的时间的影响。结果还表明，一旦 EDSS 评分达到 4 分而不是 3 分，MS 进展就独立于初始临床数据，因为从 EDSS 3 到分配 EDSS 4 的时间与预测变量相关。分配 4 分和 6 分之间的时间数据差异很大，因为中位时间不受任何预测变量的影响。
We sought to identify predictive clinical factors of disability during initial course in multiple sclerosis (MS) patients.A total of 2871 MS patients from the LORSEP (Lorraine Multiple Sclerosis) population-based cohort were analyzed. The relationships between baseline demographic, clinical predictors and time to assignment of Expanded Disability Status Scale (EDSS) scores of 3, 4 and 6 were assessed using a Cox regression model.Multivariate analysis showed that, for relapsing-remitting patients, a shorter time to assignment of an EDSS score of 4 was associated with an older age of onset of MS and incomplete recovery from the first relapse. Median times were not influenced by gender or the time between the first two relapses. The results also demonstrated that MS progression is independent of the initial clinical data once an EDSS score of 4 is reached rather than a score of 3 because the time from EDSS 3 to assignment of EDSS 4 were correlated with predicting variables. The data were very different for the time between assignment of scores of 4 and 6 because the median times were not influenced by any of the predicting variables.