Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with Helicobacter pylori Infection
Endoscopic Nodular Gastritis in Dyspeptic Adults: Prevalence and Association with Helicobacter pylori Infection
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DOI：
10.1159/000252833
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发表时间：
2010-01-01
影响因子：
3.2
通讯作者：
El-Dousari, Ahmad
中科院分区：
文献类型：
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作者：
Al-Enezi, Saleh A.;Alsurayei, Saqer A.;El-Dousari, Ahmad
目的：目的探讨成人消化不良患者内镜下结节性胃炎（NG）的发生率、组织学特征及其与幽门螺杆菌感染的关系。研究对象和方法：2006年9月1日至2007年8月31日期间，对2，142例患者进行了回顾性内镜报告审查，确定了67例NG患者。32例NG患者（第1组）在上消化道内镜检查期间进行了胃活检，并进行了H。pylori感染的患者与32名年龄和性别匹配的消化不良患者进行比较。他们在同一时期接受了内窥镜检查，结果正常，并有可用的活组织检查，对H。pylori感染（对照组，组2）。相关的临床数据从患者的记录中获得。一位经验丰富的病理学家评估活检的炎症、活动、腺萎缩、肠化生、H的存在和密度的存在和分级。幽门螺杆菌和淋巴滤泡或聚集体的存在。结果：67例（3.1%）患者中发现NG。在组织学检查中，第1组的胃炎程度明显更高（p < 0.001）。H. pylori感染在第1组中显著高于第2组（P < 0.001）。螺杆pylori密度与胃炎严重程度呈显著正相关（r = 0.57，P < 0.001）。内镜下H. pylori感染具有较高的特异性（96.8%）和阳性预测值（93.3%）。结论：本研究概述了在科威特消化不良患者队列中发现的NG的临床病理学特征，并证实了与H。幽门感染然而，我们的研究有一个局限性，即所有NG患者的组织病理学评估是不可行的。版权所有（C）2009 S. Karger AG，巴塞尔
Objective: To determine the prevalence and histological features of endoscopic nodular gastritis (NG) in adult dyspeptic patients and its relation to Helicobacter pylori infection. Subjects and Methods: A retrospective endoscopic report review of 2,142 patients identified 67 patients with NG during the period from 1 September 2006 to 31 August 2007. A subset of 32 NG patients (group 1) who had had gastric biopsies during upper gastrointestinal endoscopy and had been evaluated for H. pylori infection were compared to 32 age- and gender-matched dyspeptic patients. They had undergone endoscopy during the same period, which yielded normal results, and had available biopsies that were similarly evaluated for H. pylori infection (controls, group 2). Pertinent clinical data were obtained from the patients' records. An experienced pathologist assessed the biopsies for the presence and grade of inflammation, activity, glandular atrophy, intestinal metaplasia, presence and density of H. pylori and presence of lymphoid follicles or aggregates. Results: NG was identified in 67 (3.1%) patients. On histological examination, group 1 had a significantly higher grade of gastritis (p < 0.001). The presence and density of H. pylori infection was significantly higher in group 1 (p < 0.001). The H. pylori density correlated significantly with the severity of gastritis (r = 0.57, p < 0.001). The endoscopic performance of NG on H. pylori infection had high specificity (96.8%) and positive predictive value (93.3%). Conclusion: This study outlined the clinicopathological features of NG identified among a cohort of dyspeptic patients in Kuwait and confirmed the close association with H. pylori infection. However, our study has a limitation in that histopathologic assessment of all NG patients was not feasible. Copyright (C) 2009 S. Karger AG, Basel