Gemistocytic astrocytes in gliomas. An autoradiographic study.
Gemistocytic astrocytes in gliomas. An autoradiographic study.
复制标题
神经胶质瘤中的双星细胞星形胶质细胞。
DOI：
--
复制
发表时间：
1975
影响因子：
3.2
通讯作者：
W. Ellis
中科院分区：
文献类型：
--
作者：
T. Hoshino;C. Wilson;W. Ellis
七名脑胶质瘤患者静脉注射氚化胸苷（3-H-T）。在接下来的四小时内切除的活检标本以及在 3-H-T 单次脉冲后三周至六个月获得的其中三名患者的尸检标本的放射自显影显示以下内容：（a）尽管总体标记指数高达 5-10%（标记的细胞占总细胞群的百分比），但活检标本中没有标记宝石细胞星形胶质细胞，只有少数巨型星形胶质细胞； (b)尽管总体标记指数急剧下降，但尸检标本中仍出现分散的标记基因细胞灶。在这些相同标本的组织学切片中，基因细胞和巨细胞作为受辐射肿瘤中的主要细胞类型、在变性病灶附近的大簇中以及在退行性病灶中作为孤立的细胞出现。这些发现表明：1）宝石细胞和巨星形胶质细胞在起源和生长潜力方面相似，尽管形态上存在微小差异； 2）这些细胞增殖缓慢（如果有的话），并且与肿瘤内的退化变化密切相关； 3）这些细胞可能反映了邻近肿瘤细胞的深刻增殖活性； 4）肿瘤整体的标记指数和恶性潜能取决于分裂较快的肿瘤成分。因此，如果基因细胞和巨细胞表明存在恶性肿瘤，那么它们是次要的，而生物无害的宝石细胞可能会在细胞增殖所需底物的激烈竞争中成为失败者。
Tritiated thymidine (3-H-T) was administered intravenously to seven patients with cerebral gliomas. Autoradiographs of biopsy specimens excised within the next four hours and of autopsy specimens from three of these patients obtained three weeks to six months after the single pulse of 3-H-T revealed the following: (a) no gemistocytic astrocytes and only a few giant astrocytes were labeled in biopsy specimens, despite a high overall labeling index of 5-10% (percentage of cells labeled in the total cell population); and (b) scattered foci of labeled genistocytes occurred in autopsy specimens, despite a sharp drop in overall labeling index. In histologic sections of these same specimens, genistocytes and giant cells occurred as the major cell types in an irradiated tumor, in large clusters near foci of degeneration, and as isolated cells in anaplastic foci. These findings suggest that: 1) gemistocytes and giant astrocytes are similar in origin and growth potential regardless of minor variations in morphology; 2) these cells multiply slowly, if at all, and are closely related to regressive changes within the tumor; 3) these cells may reflect profound proliferative activity in adjacent neoplastic cells; and 4) the labeling index and malignant potential of the tumor as a whole depend upon the more rapidly dividing tumor elements. Thus, if genistocytes and giant cells indicate malignancy, they do so secondarily, and the biologically harmless gemistocyte may be the loser in an intense competition for the substrates needed in cell proliferation.