Hox gene regulation and timing in embryogenesis.
Hox gene regulation and timing in embryogenesis.
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DOI：
10.1016/j.semcdb.2014.06.005
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发表时间：
2014-10
影响因子：
7.3
通讯作者：
Thomas Montavon;N. Soshnikova
中科院分区：
文献类型：
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作者：
Thomas Montavon;N. Soshnikova
Hoxgenes是两侧对称动物胚胎发育的关键调节因子。它们表现出独特的转录调节模式，其中基因沿着染色体的位置对应于发育期间其表达的时间和地点。这些基因在原条中的顺序时间激活有助于确定它们随后沿胚胎前后轴沿着的表达模式，但这两个共线过程之间的精确对应关系尚未完全理解。此外，脊椎动物的Hoxgenes沿着沿着次级身体轴（如发育中的四肢）进化出类似的调节模式。我们回顾了目前的理解激活，维护和沉默ofHox基因的表达在这些不同的背景下的机制，并讨论其基因组组织的进化意义。
Hoxgenes are critical regulators of embryonic development in bilaterian animals. They exhibit a unique mode of transcriptional regulation where the position of the genes along the chromosome corresponds to the time and place of their expression during development. The sequential temporal activation of these genes in the primitive streak helps determining their subsequent pattern of expression along the anterior–posterior axis of the embryo, yet the precise correspondence between these two collinear processes is not fully understood. In addition, vertebrateHoxgenes evolved similar modes of regulation along secondary body axes, such as the developing limbs. We review the current understanding of the mechanisms operating during activation, maintenance and silencing ofHoxgene expression in these various contexts, and discuss the evolutionary significance of their genomic organization.