Predicting survival of patients with bone metastasis of unknown origin.
Predicting survival of patients with bone metastasis of unknown origin.
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DOI：
10.3389/fendo.2023.1193318
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
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作者：
不明原因的骨转移是一种罕见且具有挑战性的情况，很少有报道。因此，本研究旨在分析不明原因骨转移患者的临床病理特征和生存危险因素。我们基于监测、流行病学和最终结果（SEER）数据库回顾性分析了2010年至2016年不明原因骨转移患者的临床数据。首先通过应用单变量 Cox 回归分析来分析总生存期 (OS) 和癌症特异性生存期 (CSS)。然后，我们进行多变量分析以确认独立的生存预测因子。总共，我们确定了 1224 名不明原因骨转移患者进行生存分析，其中 704 名男性（57.5%）和 520 名女性（42.5%）。不明原因骨转移患者的1年OS率为14.50%，CSS率为15.90%。在单变量和多变量分析中，种族、脑转移、肝转移、放疗和化疗是 OS 的显着危险因素（p <0.05）。至于CSS，单变量和多变量分析均显示无脑转移、无肝转移、放疗和化疗与生存率增加相关（p <0.05）。不明原因骨转移的患者预后极差。放疗和化疗有利于延长这些患者的生存期。
Bone metastasis of unknown origin is a rare and challenging situation, which is infrequently reported. Therefore, the current study was performed to analyze the clinicopathologic features and risk factors of survival among patients with bone metastasis of unknown origin. We retrospectively analyzed the clinical data for patients with bone metastasis of unknown origin between 2010 and 2016 based on the Surveillance, Epidemiology, and End Results (SEER) database. Overall survival (OS) and cancer-specific survival (CSS) were first analyzed by applying univariable Cox regression analysis. Then, we performed multivariable analysis to confirm independent survival predictors. In total, we identified 1224 patients with bone metastasis of unknown origin for survival analysis, of which 704 males (57.5%) and 520 females (42.5%). Patients with bone metastasis of unknown origin had a 1-year OS rate of 14.50% and CSS rate of 15.90%, respectively. Race, brain metastasis, liver metastasis, radiotherapy, and chemotherapy were significant risk factors of OS on both univariable and multivariable analyses (p <0.05). As for CSS, both univariable and multivariable analyses revealed that no brain metastasis, no liver metastasis, radiotherapy, and chemotherapy were associated with increased survival (p <0.05). Patients with bone metastasis of unknown origin experienced an extremely poor prognosis. Radiotherapy and chemotherapy were beneficial for prolonging the survival of those patients.
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影响因子：
3.8
作者：
Huang Z;Hu C;Liu K;Yuan L;Li Y;Zhao C;Hu C
通讯作者：
Hu C
影响因子：
3.9
作者：
通讯作者：
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影响因子：
5.2
作者：
Zhang W;Ji L;Wang X;Zhu S;Luo J;Zhang Y;Tong Y;Feng F;Kang Y;Bi Q
通讯作者：
Bi Q
影响因子：
4.7
作者：
Dong S;Yang H;Tang ZR;Ke Y;Wang H;Li W;Tian K
通讯作者：
Tian K
DOI：
10.1007/s44231-022-00014-3
发表时间：
2022-12-01
期刊：
Intensive care research
影响因子：
--
作者：
Amadasu, Efosa;Panther, Eric;Lucke-Wold, Brandon
通讯作者：
Lucke-Wold, Brandon