Increased bone mineral content and bone size in the femoral neck of men with hip osteoarthritis
Increased bone mineral content and bone size in the femoral neck of men with hip osteoarthritis
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DOI：
10.1136/ard.61.2.145
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发表时间：
2002-02-01
影响因子：
27.4
通讯作者：
Kröger, H
中科院分区：
文献类型：
--
作者：
Arokoski, JPA;Arokoski, MH;Kröger, H
目的：尽管临床研究结果支持髋关节骨关节炎（OA）与骨矿物质密度（BMD）增加相关的观点，但该主题仍存在争议。因此，本研究开始调查髋关节OA的严重程度和股骨和跟骨BMD之间的关系。方法：根据美国流变学学会标准的髋关节OA的分类，27名男性（年龄47-64岁）与单侧或双侧髋关节OA和30名年龄匹配的健康男性进行了研究。平片采用Li’s评分从0（无OA）到4（严重OA）分级。根据临床髋关节OA患者的最高影像学评分侧，29.6%为1级，29.6%为2级，40.8%为3级。双能X线骨密度仪测量股骨近端骨矿含量（BMC）、面积BMD（BMD areal）和骨尺寸（面积和宽度）。从骨的中心区域测量跟骨的BMD面积。容积测量，股骨颈的磁共振图像被用来创建一个BMD测量，纠正股骨颈体积（BMDmri）。结果：有研究组之间的体重，或体重指数没有差异。OA组和对照组之间股骨近端（股骨颈和转子）或跟骨的任何亚区的BMD面积均无显著差异。两组之间股骨颈的BMDmri也没有差异。然而，股骨颈的BMC高出18%（p
Objectives: Even though clinical findings support the idea that hip osteoarthritis (OA) is associated with increased bone mineral density (BMD), the subject remains controversial. This study was therefore initiated to investigate the relation between the severity of hip OA and femoral and calcaneal BMD.Methods: On the basis of the American College of Rheumatology criteria on classification of OA of the hip, 27 men (aged 47-64 years) with unilateral or bilateral hip OA and 30 age matched randomly selected healthy men were studied. Plain radiographs were graded using Li's scale from 0 (no OA) to 4 (severe OA). According to the side of the highest radiographic score from the patients with clinical hip OA, 29.6% had grade 1, 29.6% grade 2, and 40.8% grade 3 OA. Bone mineral content (BMC), areal BMD (BMDareal), and bone dimensions (area and width) were measured by dual x ray absorptiometry at the proximal femur. BMDareal of the calcaneus was measured from the central area of the bone. Volumetric measurements from, magnetic resonance images of the femoral neck were used to create a BMD measure that was corrected for the femoral neck volume (BMDmri).Results: There were no differences in weight, or body mass index between the study groups. There were no significant BMDareal differences in any of, the subregions of the proximal femur (femoral neck and trochanter) or calcaneus between the OA and control groups. Neither did the BMDmri of the femoral neck differ between the groups. However, the BMC of the femoral neck was 18% higher (p