Intestinal dysmotility in inflammatory bowel disease: mechanisms of the reduced activity of smooth muscle contraction
Intestinal dysmotility in inflammatory bowel disease: mechanisms of the reduced activity of smooth muscle contraction
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DOI：
10.1163/156856005774423773
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发表时间：
2005-01-01
影响因子：
5.8
通讯作者：
Ohama, Takashi
中科院分区：
文献类型：
--
作者：
Ozaki, Hiroshi;Hori, Masatoshi;Ohama, Takashi
炎症抑制肠道运动，继而导致肠道菌群异常生长。这种菌群失调在粘膜炎症的发病机制中起着一定的作用，而黏膜炎症又会加重肠道的运动障碍。因此，了解炎症肠管运动功能改变的机制是很重要的。最近的研究表明，炎症性肠道运动障碍的分子机制。这些包括肌球蛋白轻链磷酸酶活性的增加和平滑肌细胞离子通道活性的改变。
Inflammation suppresses intestinal motility, which secondarily induces abnormal growth of intestinal flora. Disturbance of this flora plays a role in the pathogenesis of mucosal inflammation, which in turn aggravates the intestinal dysmotility. Therefore, it is important to know the mechanism of alteration in motor function in the inflamed intestine. Recent studies have shown molecular mechanisms responsible for the motility disorder in the inflamed gut. These include an increase in the activity of myosin light-chain phosphatase and an alteration of ion channel activity in smooth muscle cells.