The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease.
The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease.
复制标题
甘油三酯和葡萄糖指数 (TyG) 是识别非酒精性脂肪肝的有效生物标志物
DOI：
10.1186/s12944-017-0409-6
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发表时间：
2017-01-19
影响因子：
4.5
通讯作者：
Yu X
中科院分区：
文献类型：
--
作者：
Zhang S;Du T;Zhang J;Lu H;Lin X;Xie J;Yang Y;Yu X
背景甘油三酯和葡萄糖指数（TyG）已被认为是胰岛素抵抗的一个标志物.我们的目的是调查的能力，通过比较丙氨酸氨基转移酶（ALT）的预测值，以确定个人在非酒精性脂肪肝疾病（NAFLD）的风险。MethodsA横断面研究进行了中国健康体检队列的10 761人年龄在20岁以上。结果与TyG最低四分位数的参与者相比，NAFLD的校正比值比（OR）和95%置信区间（CI）分别为1.8（1.5-2.1）、3.0（2.5-3.5）和6.3 TyG第二、第三和第四分位数的患者的OR（5.3-7.5），而NAFLD的相应OR（95%CI）为1.5 ALT的上三个四分位数分别为1.3-1.7、1.9（1.6-2.2）和3.1（2.6-3.7）。这些结果表明TyG与NAFLD风险相关性上级于ALT。根据ROC分析，TyG用于NAFLD的最佳截断点为8.5，ROC曲线下面积（AUC）为0.782（95%CI 0.773-0.790），灵敏度和特异性分别为72.2%和70.5%。TyG的AUC大于ALT的AUC（0.715（95% CI 0.705-0.725），P <0.0001），而TyG与ALT联合使用时AUC最大（0.804（95% CI 0.795-0.812），P <0.0001）。TyG阈值8.5对NAFLD的诊断具有较高的敏感性，可作为中国成人NAFLD的诊断标准。
BackgroundThe triglyceride and glucose index (TyG) has been proposed as a marker of insulin resistance. We aimed to investigate the ability of TyG, through comparing with the predictive value of alanine aminotransferase (ALT), to identify individuals at risk for nonalcoholic fatty liver disease (NAFLD).MethodsA cross-sectional study was conducted in a Chinese health examination cohort of 10 761 people aged above 20 years. NAFLD was diagnosed by ultrasonography.ResultsCompared with the participants in the lowest quartile of TyG, the adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were 1.8 (1.5–2.1), 3.0 (2.5–3.5), and 6.3 (5.3–7.5) for those in the second, the third, and the fourth quartile of TyG, whereas the corresponding ORs (95% CI) for NAFLD were 1.5 (1.3–1.7), 1.9 (1.6–2.2), and 3.1 (2.6–3.7) for the upper three quartiles of ALT. These results suggested that TyG was superior to ALT in association with NAFLD risk. According to the ROC analysis, the optimal cut-off point of TyG for NAFLD was 8.5 and the area under the ROC curve (AUC) was 0.782 (95% CI 0.773–0.790), with 72.2 and 70.5% sensitivity and specificity, respectively. The AUC of TyG was larger than that of ALT (0.715 (95% CI 0.705–0.725),Pfor difference <0.0001), whereas the largest AUC was obtained when adding TyG to ALT (0.804 (95% CI 0.795–0.812),Pfor difference <0.0001).ConclusionsTyG is effective to identify individuals at risk for NAFLD. A TyG threshold of 8.5 was highly sensitive for detecting NAFLD subjects and may be suitable as a diagnostic criterion for NAFLD in Chinese adults.