Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop
Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop
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DOI：
10.1126/science.aba4177
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发表时间：
2021-03-26
期刊：
影响因子：
56.9
通讯作者：
Tian, Zhigang
中科院分区：
文献类型：
--
作者：
Bai, Lu;Vienne, Margaux;Tian, Zhigang
导致组织驻留淋巴细胞（包括肝脏1型先天淋巴细胞（ILC 1））发育的途径仍不清楚。我们在这里显示，成年小鼠肝脏含有来自胎肝的Lin（-）Sca-1（+）Mac-1（+）造血干细胞。该群体包括Lin-CD 122（+）CD 49 a（+）祖细胞，其可以产生肝脏ILC 1，但不能产生传统的自然杀伤细胞。肝脏ILC 1自身产生的干扰素-γ（IFN-γ）通过影响其IFN-γ R+肝祖细胞促进这些细胞原位发育。因此，IFN-γ依赖性环驱动肝脏ILC 1原位发育，突出了髓外造血对肝脏内区域免疫组成的贡献。
The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. We show here that the adult mouse liver contains Lin(-)Sca-1(+)Mac-1(+) hematopoietic stem cells derived from the fetal liver. This population includes Lin-CD122(+)CD49a(+) progenitors that can generate liver ILC1s but not conventional natural killer cells. Interferon-gamma (IFN-gamma) production by the liver ILC1s themselves promotes the development of these cells in situ, through effects on their IFN-gamma R+ liver progenitors. Thus, an IFN-gamma-dependent loop drives liver ILC1 development in situ, highlighting the contribution of extramedullary hematopoiesis to regional immune composition within the liver.