Neisseria gonorrhoeae Infection in Women Increases With Rising Gonococcal Burdens in Partners: Chlamydia Coinfection in Women Increases Gonococcal Burden.
Neisseria gonorrhoeae Infection in Women Increases With Rising Gonococcal Burdens in Partners: Chlamydia Coinfection in Women Increases Gonococcal Burden.
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女性淋球菌感染随着伴侣淋球菌负担的增加而增加：女性衣原体合并感染会增加淋球菌负担。
DOI：
10.1093/infdis/jiac408
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Rice,Pet
中科院分区：
文献类型：
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作者：
Su,Xiaohong;Le,Wenjing;Zhu,Xiaofeng;Li,Sai;Wang,Baoxi;Madico,Guillermo;Yang,Zhaoyan;Chaisson,ChristineE;McLaughlin,RobertE;Gandra,Sumanth;Yoon,Jungwon;Zheng,Bo;Lewis,LisaA;Gulati,Sunita;Reed,GeorgeW;Ram,Sanjay;Rice,Pet
背景与男性性伴侣接触的女性淋病奈瑟菌感染的可能性随着N.淋病负担和增强沙眼衣原体没有defined.MethodsWe确定男性尿道炎和他们的定期女性性伴侣。暴露于N.男性淋病负担与N.淋病感染者与未感染者的关系N.采用逻辑回归法估计男性伴侣负担的妇女淋病感染率。C.协会沙眼感染和N.淋病负担的妇女调整男性partners.ResultsIn的负担，估计的线性regression，共1816名男性入组; 202人有≥2个合作伙伴，91人确认一夫一妻制，并登记入组; 77%已婚。70人是N的合伙人。男性淋病感染者58例（83%）。淋病感染者26例（45%）;沙眼感染受感染的妇女的伴侣的N值是受感染妇女的9.3倍。淋病负担高于未感染妇女的伴侣（P= 0.0041）。N.淋病感染的妇女与上四分位数的N。与第一个四分位数（P= 0.032）相比，伴侣淋病负担增加（优势比≥ 2.97）。淋病菌C.沙眼衣原体合并感染者是非沙眼衣原体感染者的2.82倍。未感染沙眼的女性（P= 0.036）。淋病感染在其伴侣感染较高N的妇女中增加。淋球菌沙眼感染与N增加有关。女性淋病负担。
BackgroundLikelihood ofNeisseria gonorrhoeaeinfection in women exposed to male sex partners with increasingN. gonorrhoeaeburdens and enhancement byChlamydia trachomatisis not defined.MethodsWe identified men with urethritis and their regular female sex partners. Exposure toN. gonorrhoeaeburdens in men was compared inN. gonorrhoeae-infected versus -uninfected partners. Association ofN. gonorrhoeaeinfection in women with burdens in male partners was estimated using logistic regression. Association ofC. trachomatiscoinfection andN. gonorrhoeaeburdens in women adjusted for burdens in male partners was estimated by linear regression.ResultsIn total, 1816 men were enrolled; 202 had ≥2 partners, 91 who confirmed monogamy and were enrolled; 77% were married. Seventy were partners ofN. gonorrhoeae-infected men; 58 (83%) wereN. gonorrhoeaeinfected, 26 (45%)C. trachomatiscoinfected. Infected women had partners with 9.3-fold higherN. gonorrhoeaeburdens than partners of uninfected women (P= .0041). Association ofN. gonorrhoeaeinfection in women with upper quartiles ofN. gonorrhoeaeburdens in partners increased (odds ratios ≥ 2.97)compared to the first quartile (P= .032).N. gonorrhoeaeburdens inC. trachomatis-coinfected women were 2.82-fold higher than inC. trachomatis-uninfected women (P= .036).ConclusionsN. gonorrhoeaeinfections increased in women whose partners were infected with higherN. gonorrhoeaeburdens.C. trachomatiscoinfection was associated with increasedN. gonorrhoeaeburdens in women.