Global cognitive performance and frailty in non-demented community-dwelling older adults: Findings from the Sasaguri Genkimon Study
Global cognitive performance and frailty in non-demented community-dwelling older adults: Findings from the Sasaguri Genkimon Study
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DOI：
10.1111/ggi.12546
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发表时间：
2016-06-01
影响因子：
3.3
通讯作者：
Kumagai, Shuzo
中科院分区：
文献类型：
--
作者：
Chen, Sanmei;Honda, Takanori;Kumagai, Shuzo
目的探讨非痴呆社区老年人整体认知表现与衰弱和衰弱前期的关系。方法采用2011年Sasaguri Genkimon研究基线调查数据进行横断面研究。研究样本包括1565名老年人，数据完整且无痴呆证据。采用蒙特利尔认知评估（MoCA）和迷你精神状态检查（MMSE）评估整体认知表现。虚弱状态是根据心血管健康研究标准定义的，基于五个组成部分：意外体重减轻、握力低、疲惫、低步态速度和低体力活动。结果非体弱组、体弱前组和体弱组的MoCA和MMSE总分及其域特异性评分均下降。较差的MoCA和MMSE总得分，以及它们的特定领域得分，与更大的虚弱可能性相关，但与完全调整后的前虚弱无关。MoCA总分与虚弱的关联强度大于MMSE总分。在MoCA和MMSE中，视觉空间能力和注意领域的特定领域得分始终与脆弱前和脆弱的可能性相关，即使在所有领域相互调整后也是如此。结论在功能相对健全和无痴呆的老年人群中，MoCA表现比MMSE表现与虚弱几率的相关性更强。目前的研究结果可能有助于进一步探索可能的共同途径，可以针对这两种情况进行预防和管理。
AimTo investigate the associations of global cognitive performance with frailty and pre-frailty in non-demented community-dwelling older adults.MethodA cross-sectional study was carried out using data from the baseline survey of the Sasaguri Genkimon Study in 2011. The study sample consisted of 1565 older adults with complete data and no evidence of dementia. Global cognitive performance was evaluated using the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE). Frailty state was defined using the Cardiovascular Health Study criteria, based on five components: unintentional weight loss, low grip strength, exhaustion, low gait speed and low physical activity.ResultsTotal MoCA and MMSE scores, and their domain-specific scores decreased across the non-frail, pre-frail and frail groups. Poorer total MoCA and MMSE scores, as well as their domain-specific scores, were associated with the greater likelihood of being frail, but not with pre-frailty after full adjustment. The strength of the association with frailty was greater for total MoCA score than for total MMSE score. Domain-specific scores for visuospatial abilities and attention domains in both of the MoCA and MMSE were consistently associated with the likelihood of pre-frailty and frailty, even after being mutually adjusted for all domains.ConclusionsThe MoCA performance is more strongly associated with the odds of frailty than the MMSE performance in the relatively functional and non-demented older adult population. The present findings could contribute to further exploration of possible common pathways that can be targeted in the prevention and management for both of these two conditions.